华侨大学生物医学学院/医学院导师简介：何春燕

热门关键词：华侨大学生物医学学院/医学院导师  华侨大学何春燕  硕士研究生导师  

 

何春燕教授(博导）

Address：School of Biomedical Sciences Huaqiao University Quanzhou, China 362021

Email：hecy@hqu.edu.cn

EDUCATION

Sc.D.  Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 2009

Mentor: Professor David J. Hunter

M.S.  Molecular Biology, Shanghai Institute of Biochemistry & Cell Biology 1998

Chinese Academy of Science, Shanghai, China  

B.S.  Biology and Computer Science, East China Normal University, 1995

Shanghai, China

ACADEMIC APPOINTMENTS AND RESEARCH EXPERIENCE

2015-present   School of Biomedical Sciences，Huaqiao University，Quanzhou, China  Professor，Molecular and Genetic Epidemiology & Precision Medicine Research Center

2012-present    Indiana University Richard M. Fairbanks School of Public Health (FSPH) Indianapolis, IN  

Assistant Professor, Department of Epidemiology

2009-2012   Indiana University School of Medicine (IUSM) Indianapolis, IN  

Assistant Professor, Department of Public Health

HONORS AND AWARDS

2009 The Volunteer Leadership Award Scholarship, Harvard School of Public Health

2010 Leadership in Academic Medicine Program, Indiana University School of Medicine

2011 Finalist, NIH Stadtman Investigator Search in Epidemiology Population Sciences

2012 Awardee, NIH Loan Repayment Program in Clinical Research, NCI

2013 Selected attendee to the 1st AACR workshop on: Integrative Molecular Epidemiology

2014 Awardee, NIH Loan Repayment Program in Clinical Research (renewal), NCI

2014 Finalist Trustees’ Teaching Award, Indiana University Fairbanks School of Public Health

2015 Awardee, NIH Loan Repayment Program in Clinical Research (renewal), NCI

2015 Awardee, Career Catalyst Research Grant, Susan G. Komen for Breast Cancer Research

2015 中国国家第十一批“千人计划”青年人才

2015 福建省“百人计划”优秀人才, 海外高层次人才

PEER REVIEWED PUBLICATIONS

1.      Sara Ibrahim, Weipeng Hu, Xiaoting Wang, Xiang Gao, Chunyan He, & Jinhui Chen . Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus. Scientific reports.2016. DOI: 10.1038/srep21793.

2.      Erin Wagner, Wenting Wu, Yunlong Liu, Kenneth Nephew, Jiali Han and Chunyan He .DNA methylation in tumor, adjacent non-tumorous and normal breast tissues . American-association-for-cancer-research, 2016, 76(2 Supplement)

3.      Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD., Elks CE, Franceschini N, He C, et al. Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA double strand break repair. Nat Genet. 2015. Nov;47(11):1294-303.

4.      Lunetta KL, Day F, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, Schick UM, Stolk L, Teumer A, Thompson DJ, Traglia M, Wang CA, Yerges-Armstrong LM, et al. Rare coding variants and Xlinked loci associated with age at menarche. Nat Commun. 2015. 2015 Aug 4;6:7756.

5.      Tu W, Wagner EK, Eckert GJ, Yu Z, Hannon T, Pratt JH, He C*. Associations of menarche-related genetic variants with pubertal growth in males and females. J Adolesc Health. 2015, 56(1):66-72. PMID: 25287989.

6.      He C*, and Murabito JM. Genome-wide association studies on menarche and menopause. Mol Cell Endocrinol. 2014. 25;382(1):767-79. PMID: 22613007.

7.      Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature. 2014 Oct 2;514(7520):92-7.

8.      Perry JR, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, Vernon Smith A, Stolk L, Sulem P, Weedon MN, Zhuang WV, et al. A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013. 1; 22(7):1465-72.

9.      He C*, Chasman DI, Dreyfus J, Hwang SJ, Ruiter R, Sanna S, Buring JE, Fernández-Rhodes L, Franceschini N, Hankinson SE, Hofman A, Lunetta KL, Palmieri G, Porcu E, Rivadeneira F, Rose LM, Splansky GL, Stolk L, Uitterlinden AG, Chanock SJ, Crisponi L, Demerath EW, Murabito JM, Ridker PM, Stricker BHCh, Hunter DJ. Reproductive aging associated common genetic variants and the risk of breast cancer. Breast Cancer Res. 2012. 20;14(2):R54.

10.  Zhang Y, Wagner EK, Cai Q, Shu XO, Zheng W, He C*¶, Long J*¶.. Long intergenic non-coding RNA transcriptome in human breast cancer. 2013. Submitted. (¶ contribute equally, co-senior author).

11.  Chung JW, Jin Z, Mei W, Strack S, He C, Lau G. Yang J. Regulation of nuclear-cytoplasmic shuttling of Family with sequence similarity 13, member A (Fam13a) by B56-containing PP2As and Akt. J Biol Chem. 2014.In revision.

12.  He C*. Genetics of age at menarche. eLS. July 2014. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0025304. (senior and corresponding author) *

13.  He C*, and Murabito JM. Genome-wide association studies on menarche and menopause. Mol Cell Endocrinol. 2014. 25;382(1):767-79. PMID: 22613007.

14.  He C*, Chasman DI, Dreyfus J, Hwang SJ, Ruiter R, Sanna S, Buring JE, Fernández-Rhodes L, Franceschini N, Hankinson SE, Hofman A, Lunetta KL, Palmieri G, Porcu E, Rivadeneira F, Rose LM, Splansky GL, Stolk L, Uitterlinden AG, Chanock SJ, Crisponi L, Demerath EW, Murabito JM, Ridker PM, Stricker BHCh, Hunter DJ. Reproductive aging associated common genetic variants and the risk of breast cancer. Breast Cancer Res. 2012. 20;14(2):R54. PMID: 22433456.

15.  Stolk L, Perry JRB, Chasman DI, He C † (4th out of 172 coauthors), et al. Meta-analyses identify 13 loci associated with age at menopause and novel loci highlight DNA repair and immune pathways. Nat Genet. 2012. 44(3):260-8. PMID: 22267201. ( † one of the lead authors).

16.  Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C † (6th out of 175 coauthors), et al. Thirty novel loci for age at menarche identified by a meta-analysis of genome wide association studies. Nat Genet. 2010; 42(12):1077-85. PMID: 21102462. ( † one of the lead authors)

17.  He C*, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. A large-scale candidate-gene association study of age at menarche and age at natural menopause. Hum Genet. 2010; 128(5): 515-527. PMID: 20734064 (*corresponding author)

18.  He C*, Qureshi AA, Han J. Polymorphisms in genes involved in oxidative stress and their interactions with lifestyle factors on skin cancer risk. J Dermatol Sci. 2010, 60(1): 54-56. PMID: 20727719 (*corresponding author)

19.  He C*, Nan H, Qureshi AA, Han J. Genetic Variants in P53BP1 gene and risk of skin cancer. J Investigative Dermatol. 2010; 130, 2850–2853. (*corresponding author)

20.  He C*, Zhang C, Hunter DJ, Hankinson SE, Louis GMB, Hediger ML, Hu FB. Age at menarche and risk of type 2 diabetes: results from two large prospective cohorts. Am J Epidemiol. 2010; 171(3): 334-344. (*corresponding author)

21.  He C*, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock S, Ridker PM, Hunter DJ, Chasman DI. Genome-wide association studies identify novel loci associated with age at menarche and age at natural menopause. Nat Genet. 2009, 41(6): 724-728. PMID: 19448621 (*corresponding author)

22.  He C*, Tamimi RM, Hankinson SE, Hunter DJ, Han J. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat. 2009; 113(3): 585-594. PMID: 18340529 (*corresponding author)

23.  Gajdos ZK, Butler JL, Henderson KD, He C, Supelak P, Euyud M et al., Association studies of common variants in ten hypogonadotropic hypogonadism genes with age at menarche. J Clin Endocrinol Metab. 2008; 93(11): 4290-4298.

24.  Aguiar RC, Takeyama K, He C, Kreinbrink K, Shipp MA. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem. 2005; 280(40):33756-33765.

25.  Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, and Shipp MA. The BAL-binding Protein BBAP and Related Deltex Family Members Exhibit Ubiquitin-Protein Isopeptide Ligase Activity. J Biol Chem. 2003; 278: 21930-21937.

26.  Kirmaier C, Cua A, He C, Holten D, and Bocian DF. Probing M-Branch Electron Transfer and Cofactor Environment in the Bacterial Photosynthetic Reaction Center by Addition of a Hydrogen Bond to the M-side Bacteriopheophytin. J Phys Chem. B 2002; 106: 495-503.

27.  Kirmaier C, He C, and Holten D. Manipulating the direction of electron transfer in the bacterial reaction center by swapping Phe for Tyr near BChl(M) (L181) and Tyr for Phe near BChl(L)(M208). Biochemistry 2001; 40(40): 12132-12139.

国际学术会议大会报告:

2014.10     “Genetics of age at menarche and breast cancer risk” 2nd International Conference on Endocrinology  Chicago, IL,USA

2012.06     “Age at menarche and type 2 diabetes” 1st Annual World Congress of Diabetes Beijing, China

2010.04     “Breast cancer risk prediction: Incorporating common genetic variants identified from genome-wide association studies” 3rd Annual World Cancer Congress: Epidemiology, Genetics and Prevention  Shanghai, China

特邀报告:

2014.05    “Post-GWAS functional characterization of breast cancer risk loci”

2014       Cancer Research Day Indiana University Simon Cancer Center, Indianapolis, IN, USA

2013.09    “GWAS and post-GWAS of breast cancer” Center for Computation Biology and Bioinformatics Indiana University School of Medicine, Indianapolis, IN, USA

2013.08    “eQTL analysis in normal breast tissue” Division of Epidemiology Vanderbilt University Medical Center, Nashville, TN, USA

2013.05    “Integration of GWAS and gene expression to characterize functions of  breast cancer risk loci”Genetic Epidemiology Branch, Division of Cancer Epidemiology & Genetics National Cancer Institute (NCI), Rockville, MD, USA

2012.06    “A genomic approach to search for genetic determinants of complex traits” Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Science, QingDao, China

2012.06    “Genetic epidemiological research on breast cancer” Sichuan University, West China Center of Medical Sciences Sichuan, China

2011.11    “Reproductive aging and complex diseases: the genetic links” Earl Stadtman Mini-Symposium National Health Institute (NIH), Bethesda, MD, USA

2011.02    “Integrating geographic information with genetic epidemiology” Health Geographics Symposium, Center for Health Geographic Indiana University, Indianapolis, IN, USA

2011.02    “Genetic determinants of reproductive aging and their associations with breast cancer”Section of Pediatric Endocrinology and Diabetology Riley Hospital for Children, Indianapolis, IN, USA

2010.03    “Reproductive traits and their genetic determinants” Department of OB/GYN Grand Round Indiana University School of Medicine, Indianapolis, IN, USA

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