厦门大学药学院导师介绍：方美娟
作者：聚创厦大考研网-小厦老师
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发布时间： 2018-09-08 14:06
微信号： H17720740258
方美娟博士，副教授
教育背景：
1997.9—2001.7 厦门大学化学化工学院化学系，理学学士
2001.9—2006.7 厦门大学化学化工学院，有机化学专业，理学博士
工作经历：
2006-2011起，厦门大学药学院，药学系，讲师，硕导。
2014.06-2015.06，美国加州大学旧金山分校， Research Associate。
2011起，厦门大学药学院，副教授，硕导。
研究简介：
主要从事：小分子代谢；靶向性抗肿瘤或抗HIV活性化合物小分子的设计、合成及活性研究，药物小分子和蛋白大分子间相互作用的研究。现已在Analytica Chimica Acta. Rapid Commun. Mass Spectrom. Organic Letters、Tetrahedron Lett、Journal of Asian Natural Products Research等国外重要刊物上发表三十多篇研究型SCI论文和申请国内专利4项。主持国家自然科学基金（青年项目）1项，省部级课题1项，横向课题5项，参与多项国家、省部级课题。
近5年发表的研究性论文：
1.Liu, L. N.; Fu, T. T.; Xu, X. F.; Fu, C.; Fang, M. J.*; Liu, Y.; Xu, P. X. and Zhao, Y. F.*. Tracing the nitrogen metabolites of glycine using 15N-glycine and mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 645-653.
2.Fang, M. J.*; Zhang, H.; Liao, C.; Qiu, Y. K.; Fang, H.; Zheng, Z. Y.; Gao, X.; Zhao, Y. F.;Wu, Z.; Fragmentation Mechanisms about Phosphorylation-Dephosphorylation Involved in Amino Acid Ester Isopropyl Phosphoramidates of Brefeldin A Studied by Tandem Mass Spectrometry and Stable Isotopic Labeling, Analytica Chimica Acta. 853 (2015) 391-401.
3.Chen, J. W.; He, Z.; Wu, Z.; Fang, M. J.* and Fang, H. (2z, 4E)-1-(5-fluoro-2- hydroxyphenyl)-5-(4-fluorophenyl)-3-hydroxypenta-2,4-dien-1-one. Acta Cryst. (2014). E70, o88.
4.Qiu, Y. K.; Yan, X.; Fang, M. J.; Chen, L.; Wu, Z.; Zhao, Y. F. Two-dimensional countercurrent chromatography × highperformance liquid chromatography for preparative isolation of toad venom. Journal of Chromatography A. 1331 (2014) 80-89.
5.Yan, X.; Tang, X. X.; Chen, L.; Yi, Z. W.; Fang, M. J.; Wu, Z. and Qiu, Y. K.. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Mar. Drugs, 12 (2014) 2156-2163.
6.Qiu, Y. K.; Chen, F. F.; Zhang, L. L. Yan, X.; Chen, L.; Fang, M. J.; and Wu, Z.. Two-dimensional preparative liquid chromatography system for preparative separation of minor amount components from complicated natural products. Analytica Chimica Acta. 820 (2014) 176-186.
7.Fang M. J. *, Fang H., Li W. J., Huang D. M, Wu Z., Zhao Y. F. A new diphenyl ether from Phoma sp strain, SHZK-2. Natural Product Research, 2012, 26(13): 1224-1228.
8.Zhuang R. Q., Xu J. A., Cai Z. S., Tang G., Fang M. J. *, Zhao Y. F*. Copper-Catalyzed C_P Bond Construction via Direct Coupling of Phenylboronic Acids with H-Phosphonate Diesters. Organic Letters, 2011, 13(8): 2110-2113.
9.Fang, H.; Xie, X. L.; Hong, B. H.; Zhao, Y. F.; Fang, M. J*, Copper (I) Iodide-Catalyzed Solvent-Free Synthesis of alpha-Aminophosphonates. Phosphorus sulfur and Sillcon and the Related Elements, 2011, 186 (11): 2145-2155.
10.Fang H., Chen W. Z., Hong B. H., Zhao Y. F., Fang M. J*. Synthesis, characterizations, and crystal structures of hydroxyphosphonic acid esters. Phosphorus sulfur and Sillcon and the Related Elements, 2010, 185 (11): 2182-2193.
11.Zheng Z. Y., Liu Y., Cai Z. S., Zhang, H. W., Fang H., Fang M. J. *, Zhao Y. F. Electrospray ionization tandem mass spectrometry of phosphonate peptides. European Journal of Mass Spectrometry, 2010, 16(4): 503-509.
12.Gao, X.; Zhuang, R. Q.; Guo, J. N.; Bao, J.; Fang, M. J.; Liu, Y.; Xu, P. X.; Zhao, Y. F.. Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-speed counter-current chromatography. Journal of Separation Science, 2010, 33(2): 277-284.
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院
邮编：361102
Email: fangmj@xmu.edu.cn
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