厦门大学生命科学学院导师介绍：邓贤明
作者：聚创厦大考研网-小厦老师
点击量： 1369
发布时间： 2018-09-08 09:57
微信号： H17720740258
邓贤明 DENG Xianming, Ph.D.
教邓贤明教授博导授，博士生导师
Chemical Biology and Medicinal Chemistry Group
课题组组长
电 话: +86-592-2184180
传 真: +86-592-2181722
E-mail:xmdeng@xmu.edu.cn
Group web: http://121.192.179.196/lmpe/
2001年，厦门大学化学系化学专业，获理学学士学位；
2006年，中科院上海有机化学研究所有机化学专业，获理学博士学位；
2006年至2011年，哈佛医学院Dana-Farber癌症研究所,博士后研究；
2011年10月起，为厦门大学生命科学学院“闽江学者”特聘教授，微生物药物课题组学科带头人，入选中组部“青年千人”计划。
2001，B.Sc., Xiamen University;
2006, Ph.D., Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences.
2006-2011, Research Fellow, Dana-Farber Cancer Institute, Harvard Medical School.
2011.10-, Principal Investigator of Chemical Biology and Medicinal Chemistry Group, School of Life Sciences, Xiamen University.
主要研究领域（Research Area）
化学生物学和药物化学。在化学生物学方面，我们集中于设计并合成新颖的针对蛋白激酶（Protein Kinase）和表观遗传蛋白（Epigenetic Enzyme）的小分子抑制剂，并运用这些功能小分子为工具，发现和解决信号传导通路、神经生物学和癌症中的新问题。在药物化学方面，以化学生物学研究成果为基础，结合传统的药物化学手段（构效关系研究、药代动力学和毒理学研究）进一步优化小分子工具化合物，以期发展针对癌症等相关疾病的“靶向治疗”药物。
Our research is focused on two major areas: chemical biology and medicinal chemistry. At the interface of chemistry and biology, we use organic synthesis to create new chemical tools for studying biological problems in human health and disease. These functional small-molecule tools are applied to control and elucidate cellular signal transduction in cancer, stem cell, and neural diseases. Second, we pursue established medicinal chemistry approaches including structure activity relationship (SAR) study and pharmacokinetics modification to optimize pre-clinical drug candidates. We're working to address the following general questions: a) How can we develop small-molecule modulators with selectivity towards desired targets such as protein kinases and epigenetic enzymes? b) How can we use discovered-small-molecule tools to dissect the molecular signaling pathways? c) How can we develop the 'lead' of targeted-drug from the tool compound?
代表性论文（Selected publications）(#Co-first authorship,*Corresponding author)：
1. Fan, F.; He, Z.; Kong, L. L.; Chen, Q.; Yuan, Q.; Zhang, S.; Ye, J.; Liu, H.; Sun, X.; Geng, J.; Yuan, L.; Hong, L.; Xiao, C.; Zhang, W.; Li, Y.; Wang, P.; Huang, L.; Wu, X.; Ji, Z.; Wu, Q.; Xia, N. S.; Gray, N. S.; Chen, L.; Yun, C. H.*; Deng, X.*; Zhou, D.* Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Science Translational Medicine 2016, 8, 352ra108. (Cover story, Highlighted by Nature Reviews Gastroenterology & Hepatology)
2. Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X.; Huang, W.; Han, S.; Zhang, T.; Wang, Z.; Jiao, B.; Song, S.; Wang, H.-R.; Chen, L.; Zhou, D.; Liu, Q.; Ren, R.*; Zhang, J.*; Deng, X.* Targeting BRK-positive breast cancers with small molecule kinase inhibitors Cancer Research. 2017, 77, 175-186. (Highlighted byBioWorldTM).
3. Jiang, H.; He, H.; Chen, Y.; Huang, W.; Cheng, J.; Ye, J.; Wang, A.; Tao, J.; Wang, C.; Liu, Q.; Jin, T.; Jiang, W.*; Deng, X.*; Zhou, R.* Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J. Exp. Med. 2017, 214, 3219-3238. (Highlighted by Nature Reviews Rheumatology).
4. Liu, Z.; Li, Y.; Li, W.; Xiao, C.; Liu, D.; Dong, C.; Zhang, M.; M?kil?, E.; Kemell, M.; Salonen, J.; Hirvonen, J. T.; Zhang, H.*; Zhou, D.*; Deng, X.*; Santos, H. A.* Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics. Advanced Materials 2018, 30, e1703393.
5. Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J.; Wang, Z.; Xu, Q.; Zhang, J.; Deng, X.* Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities. J. Med. Chem. 2018, 61, 5424-5434. (Top journal in Medicinal Chemistry)
6. He, H.; Jiang, H.; Chen, Y.; Ye, J.; Wang, A.; Wang, C.; Liu, Q.; Liang, G.; Deng, X.*; Jiang, W.*; Zhou, R.* Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 2018, 9, 2550.
7. Huang, X.; Huang, W.; Li, L.; Sun, X.; Song, S.; Xu, Q.; Zhang, L.; Wei, B. G.; Deng, X.* Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis. Mol. Pharm. 2016, 13, 3756-3763.
8. Wang, Y.; Qi, S.; Zhan, Y.; Zhang, N.; Wu, A.; Gui, F.; Guo, K.; Yang, Y.; Hu, Z.; Zheng, Z.; Song, S.; Xu, Q.; Shen, Y.*; Deng, X.* Aspertetranones A-D, Meroterpenoids from the Marine Algal-associated Fungus Aspergillus sp. J. Nat. Prod. 2015, 78, 2405-10.
9. Li, D.; Huang, Y.; Song, S.; Xue, C.; Wu, Y.*; Deng, X.* Kibdelosporangium lantanae sp. nov., isolated from the rhizosphere soil of an ornamental plant, Lantana camara L. Int. J. Syst. Evol.Microbiol. 2015, 65, 2581-5.
10. Deng, X.?; Dzamko, N.?; Prescott, A.; Davies, P.; Liu, Q.; Yang, Q.; Lee, J. D.; Patricelli, M. P.; Nomanbhoy, T. K.; Alessi, D. R.; Gray, N. S. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical. Biology. 2011, 7, 203-5.
11. Yang, Q.?; Deng, X.?; Lu, B.?; Cameron, M.; Fearns, C.; Patricelli, M. P.; Yates, J. R., 3rd; Gray, N. S.; Lee, J. D. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 2010, 18, 258-67.
12. Deng, X.?; Okram, B.?; Ding, Q. ? Zhang, J.?; Choi, Y.; Adrian, F. J.; Wojciechowski, A.; Zhang, G.; Che, J.; Bursulaya, B.; Cowan-Jacob, S. W.; Rummel, G.; Sim, T.; Gray, N. S. Expanding the diversity of allosteric bcr-abl inhibitors. J. Med. Chem. 2010, 53, 6934-46.
已申请的专利
1．Gray, N. S.; Zhang, J.; Okram, B.; Deng, X.; Chang, J.; Wojciechowski, A. PCT Int. Appl. WO2009073153 (US granted).
2．Gray, N. S.; Zhang, J.; Okram, B.; Deng, X.; Chang, J.; Wojciechowski, A. PCT Int.
Appl. WO2009073153(US granted).
3．Gray, N. S.; Deng, X.; Kwiatkowski, N. P. PCT Int. Appl. WO2010080712.
4．Gray, N. S.; Zhou, W.; Deng, X. PCT Int. Appl. WO2011115725.
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