厦门大学医学院导师介绍：王海滨

王海滨 
职称：教授
“闽江学者”特聘教授/博导
国家杰出青年基金获得者
“973”项目首席科学家
学科（方向）：生殖调控
所在系部：生殖调控与生殖健康研究福建省高等学校重点实验室
办公电话：0592-2880501
邮    箱：haibin.wang@vip.163.com
研究领域：
生殖过程是一个由母体与子体共同参与的被精确调控的生理过程，其中的早期胚胎发育、胚泡着床与随后的胎盘发生是决定妊娠能否成功的关键环节。研究组主要利用动物模型结合人类临床资源和多种新兴研究策略研究早期胚胎发育、着床与胎盘发生的生理和病理调节机制，具体包括：（1）囊胚激活的分子机制；（2）子宫接受态建立和蜕膜化的分子调控网络；（3）胎盘发育过程中滋养层细胞命运分化的决定。通过对以上关键过程的研究，深入揭示妊娠建立和维持的分子机理，为预防和治疗与上述生殖过程相关的女性生殖疾病提供参考和借鉴。
学习经历:
1992~1996中国农业大学生理学专业，理学学士
2000~2001日本东京农工大农学部家畜生理学，短期交换留学生
1996~2001中国农业大学生理学专业，理学博士
工作经历：
2001~2002 美国堪萨斯大学医学中心，博士后
2002~2008 历任美国范德堡大学医学中心博士后，研究助理教授，助理教授
2008~2016  中国科学院动物研究所，研究员
2016~至今  厦门大学医学院，特聘教授
代表性成果：
Xin Q#, Kong S#, Yan J#, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Bmi-1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 128(1):175-189, 2018

Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. Dec;24(12):2013-2021, 2017

Ran H#, Kong S#, Zhang S#, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 114(18):4816-4821, 2017

Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81, 2016

Zhang S#, Kong S#, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res., 24(8):925-42, 2014

Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11(4):e1001536, 2013

Lim H* & Wang H*. Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010

Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, andWang H. Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation.Development. 135: 717-727, 2008

Xie H#, Wang H#, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK and Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.Proc Natl Acad Sci USA. 104(46): 18315-20, 2007

Wang H and Dey SK. Roadmap to embryo implantation: Clues from mouse models.Nature Review Genetics. 7 (3): 185-199, 2006

Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest. 116 (8): 2122-2131, 2006

Wang H#, Tranguch S#, Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus.Proc Natl Acad Sci USA.102 (28): 9960-9965, 2005

Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK,DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nature Medicine.10: 1074-1080, 2004

Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci USA. 100(25): 14914-14919, 2003

主持过的重要课题：

科技部重点研发计划，2017YFC1001400，人类胚胎着床调控及相关重大妊娠疾病发生机制，2017/07-2020/12，1428万，在研，主持

国家基金委重点项目，81330017，胚胎着床的表观遗传调控机制，2014/01-2018/12，290万，在研，主持

国家基金委重大项目，81490744，母-胎界面微环境训导母-胎免疫耐受的分子机制及其异常调控的致病机制，2015/01-2019/12，120万，在研，研究骨干

国家基金委重点项目，81130009，母-胎互作微环境决定妊娠结局的分子基础，2012/01-2016/12，260

，结题，主持

科技部重大科学研究计划(973)，2011CB944400，妊娠建立和维持的分子机制研究，2011/01-2015/12，552

，结题，项目首席

国家基金委杰出青年基金项目，30825015，Wnt信号通路在胚泡着床和子宫蜕膜反应中的生理作用，2008/10-2012/12，200

，结题，主持

北京市面上项目，5142015，Polycomb蛋白Ring1b和Bmi1在胚胎着床中的表观遗传调控机制，2014/01-2016/06，18万，结题，主持

北京市自然基金重点项目，5091002，胚胎滋养层干细胞的功能性分析，2009/01-2011/12，50

，结题，主持

科技部重大科学研究计划(973)，2012CBA01306，生殖病理和毒理的灵长类模型的 建立和研究，2012/01-2016/08，144万，结题，研究骨干

科技部重大科学研究计划(973)，2010CB945002，卵巢衰老及相关重大疾病的基础研究，2010/01-2014/12，190万，结题，研究骨干

所有论文列表：

Xin Q#, Kong S#, Yan J#, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Bmi-1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 128(1):175-189, 2018【查看主页 】

Zhou C, Bao H, Kong S, Lu Ji, Wang H. Developmental Aspect of Decidual Patterning.Reproductive and Developmental Medicine. June 25, 1 (2),100-114, 2, 2017【查看主页】

Xin Q#, Li M#, Wang H, Cui S, Xia G, Kong S. Transcript analysis identifies differential uterine gene expression profile beyond the normal implantation window in mice.Theriogenology. 104:55-61, 2017【查看主页 】 

Lu X, Wang R, Zhu C, Wang H, Lin HY, Gu Y, Cross JC, Wang H. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. Oct 31;21(5):1150-1159, 2017 【查看主页】

Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. Dec;24(12):2013-2021, 2017 【查看主页】

Ran H#, Kong S#, Zhang S#, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 114(18):4816-4821, 2017 【查看主页】

Jiang Y#, Kong S#, He B, Wang B, Wang H*, Lu J*. Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Cell Tissue Res. 365(2): 403-14, 2016【查看主页】

Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81, 2016【查看主页】

Xin Q, Qiu J, Cui S, Xia G, Wang H. Transcriptional activation of nuclear estrogen receptor and progesterone receptor and its regulation. Sheng Li Xue Bao. Aug 25;68(4):435-54, 2016 【查看主页】

Wu W, Tang X, Cui T, Wang H. Molecular Mechanisms of Female Reproductive Tract Development. SCIENTIA SINICA Vitae. 46(1), 66-83, 2016 【查看主页】

Li N, Liu S, Zhang HS, Deng ZL, Zhao HS, Zhao Q, Lei XH, Ning LN, Cao YJ, Wang HB, Liu S, Duan EK. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int J Mol Sci. 17(4), 2016 【查看主页】

Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY, Wang H. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr. Mar 3;10(1-2):39-55, 2016【查看主页】 

Kong S#, Han X#, Cui T, Zhou C, Jiang Y, Zhang H, Wang B, Wang H, Zhang S. MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice. Endocrine. 53(2):595-606, 2016 【查看主页】

Yuan X, Hu T, Zhao H, Huang Y, Ye R, Lin J, Zhang C, Zhang H, Wei G, Zhou H, Dong M, Zhao J, Wang H, Liu Q, Lee HJ, Jin W, Chen ZJ. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci U S A. 113(10):2708-13, 2016 【查看主页】

Wu W, Kong S, Wang B, Chen Y*, Wang H*. Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation. Cell Tissue Res. 363(2):555-65, 2016 【查看主页】

Xu Q, Wang F, Xiang Y, Zhang X, Zhao ZA, Gao Z, Liu W, Lu X, Liu Y, Yu XJ, Wang H, Huang J, Yi Z, Gao S, Li L. Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 142(22):3943-53, 2015 【查看主页】

Jiang Y, Liao Y, He H, Xin Q, Tu Z, Kong S, Cui T, Wang B, Quan S, Li B, Zhang S*,Wang H*. FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization. Sci Rep. 5:13735, 2015 【查看主页】

Zhao Z, Yu Y, Ma H, Wang X, Lu X, Zhai Y, Zhang X, Wang H, Li L. The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biol. 5(8), 2015 【查看主页】

Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H*, Lu Z*. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 5:12982, 2015【查看主页】

He H, Kong S, Liu F, Zhang S, Jiang Y, Liao Y, Jiang Y, Li Q, Wang B, Zhou Z, Wang H*, Huo R*. Rbbp7 Is Required for Uterine Stromal Decidualization in Mice. Biol Reprod.2015 Jul;93(1):13, 2015 【查看主页】

Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, Wang HB, Lin H, Fu J, Wang H. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 150(2):139-49, 2015【查看主页】

Liao Y, Jiang Y, He H, Ni H, Tu Z, Zhang S, Wang B, Lou J, Quan S*, Wang H*. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Hum Reprod. 30(7):1665-76, 2015 【查看主页】

Tang X#, Chen Y#, Ran H, Jiang Y, He B, Wang B, Kong S*, Wang H*. Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice. Biol Reprod. 92(5):118, 2015 【查看主页】

Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H, Ma T, Qiao J, Duan E. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res., 25(1):139-42, 2015【查看主页】

Pan Y, Gong Y, Ruan H, Pan L, Wu X, Tang C, Wang C, Zhu H, Zhang Z, Tang L, Zou C,Wang H, Wu XM. Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth. Cell Death Dis. 6:e1653, 2015 【查看主页】

Gong Y, Xu C, Wang J, Hu X, Hong D, Ji X, Shi W, Chen H, Wang H, Wu X. Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling. Cell Death Dis. 5:e1544, 2014 【查看主页】

Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun Q, Dean J, Li L. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nat Commun. 5:4887, 2014 【查看主页】

Zhou Z, Wang R, Yang X, Lu XY, Zhang Q, Wang YL, Wang HB, Zhu C, Lin HY, Wang H. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta. 5(11):907-18, 2014【查看主页】

Chen Y, Kong S, Tang X, Fu Y, Wang B, Zhang S*, Wang H*. Preimplantation mouse embryo is a target for opioid ligand-receptor signaling. Biol Reprod. 91(1):4, 2014 【查看主页】

Li S, Wang Y, Cao B, Wu Y, Ji L, Li Y, Liu M, Zhao Y, Qiao J, Wang HB, Wang H, Han C, Wang YL. Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26. J Clin Endocrinol Metab. 99(11):E2277-87, 2014 【查看主页】

Zhang S#, Kong S#, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear W, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*,Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res. 24(8):925-42, 2014 【查看主页】

Tu Z, Ran H, Zhang S, Xia G, Wang B*, Wang H*. Molecular Determinants of Uterine Receptivity. Int J Dev Biol. 58(2-4):147-54, 2014【查看主页】 

Xu P, Zhao Y, Liu M, Wang Y, Wang H, Li Y, Zhu X, Yao Y, Wang HB, Qiao J, Ji L, Wang YL. Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy. Hypertension. 63(6):1276-1284, 2014【查看主页】

Meccariello R, Battista N, Bradshaw HB, Wang H. Endocannabinoids and reproduction.Int J Endocrinol. 2014: 378069 【查看主页】

Meccariello R, Battista N, Bradshaw HB, Wang H. Updates in Reproduction Coming from the Endocannabinoid System. Int J Endocrinol. 2014: 412354【查看主页】

Fu Z#, Wang B#, Wang S#, Wu W#, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*,Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 90(3):52, 2014【查看主页】

Li W, Liu D, Chang W, Lu X, Wang YL, Wang HB, Zhu C, Lin HY, Zhang Y, Zhou J, Wang H. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 5:e1025, 2014 【查看主页】

Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11(4):e1001536, 2013【查看主页】

Duan EK, Wang H, Zernicka-Goetz M. Introduction to the special issue "Molecular Players in Early Pregnancy". Mol Aspects Med. 34(5):vi-vii, 2013【查看主页】

Zhang S#, Lin H#, Kong S#, Wang S, Wang HM, Wang H*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. doi:pii: S0098-2997(12)00158-6, 2013 【查看主页】

Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod. 88(1):5, 1-9, 2013 【查看主页】

Zhang S, Kong S, Lu J, Wang Q, Chen Y, Wang W, Wang B, Wang H*. Deciphering the molecular basis of uterine receptivity. Mol Reprod Dev. 80(1):8-21, 2013 【查看主页】

Lu W, Tu Z, Wang S, Lu J, Wang Q, Wang W, Wang B, Wang H, Ni H, Guo Y. Spatiotemporal expression of Wnt signaling pathway components during bovine placental development. Theriogenology. 80(8): 893-902, 2013 【查看主页】

Zhou Z, Zhang Q, Lu X, Wang R, Wang HB, Wang YL, Zhu C, Lin HY, Wang H. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis. 4: e593, 2013【查看主页】

Fu Z, Chen Y, Wu W, Wang S, Wang W, Wang B, Wang H*. Molecular and cellular aspects of blastocyst dormancy and reactivation for implantation. J Stem Cells. 8(2):59-77, 2013【查看主页】

Kong S#, Zhang S#, Chen Y, Wang W, Wang B, Chen Q, Duan E*, Wang H*. Determinants of uterine aging: lessons from rodent models. Sci China Life Sci. 55(8): 687-93, 2012 【查看主页】

Lu J#, Wang Q#, Wang B, Wang F, Wang H*. Developmental genes during placentation: insights from mouse mutants. Front. Biol. 6(4): 300-311, 2011 【查看主页】

Lim H# & Wang H#(Co-correspondence). Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010 【查看主页】

Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 107(39):16887-92, 2010 【查看主页】

Wang F, Yang J, Wang H, Xia G. Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. Prostaglandins Other Lipid Mediators. 92(1-4):25-32, 2010 【查看主页】

Chen Q, Zhang Y, Lu J, Wang Q, Wang S, Cao Y, Wang H*, Duan E*. Embryo-uterine cross-talk during implantation: The role of Wnt signaling. Mol Hum Reprod. 15(4):215-21, 2009【查看主页】

Sun X, Wang H, Okabe M, Mackie K, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. Genetic loss of Faah compromises male fertility in mice. Biol Reprod. 80(2):235-42, 2009 【查看主页】

Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 136(15):2535-43, 2009【查看主页】

Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, andWang H. Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation.Development. 135: 717-727, 2008 【查看主页】

Ray S, Xu F, Wang H, Das SK. Cooperative Control via Lef-1/Tcf-3 and ERα for Uterine Gene Regulation by Estrogen. Mol Endocrinol.22(5): 1125-40, 2008【查看主页】

Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res. 68(15):6468-76, 2008 【查看主页】

Wang H, Xie H, Dey SK. Loss of cannabinoid receptor CB1 induces preterm birth. PLoS ONE. 3(10):e3320, 2008【查看主页】

Wang H#, Xie H#, Sun X*, Kingsley PJ, Marnett LJ, Cravatt BF and Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins and Other Lipid Mediators 83: 62-74, 2007【查看主页】

Maccarrone M, Wang H, Dey SK. Antagonism of type-1 cannabinoid receptors: good for obesity, but is it safe for fertility? Clin Endocrinol(Oxf). 66(3):456-7, 2007【查看主页】

Tranguch S, Wang H, Daikoku T, Xie H, Smith DF, Dey SK. FKBP52 deficiency- conferred uterine progesterone resistance is genetic background and pregnancy stage specific. J Clin Invest. 117 (7): 1824-34, 2007【查看主页】 

Tranguch S, Chakrabarty A, Guo Y, Wang H, Dey SK. Maternal Pentraxin 3 Deficiency Compromises Implantation in Mice. Biol Reprod. 77(3): 425-32, 2007【查看主页】 

Ray S, Xu F, Li P, Sanchez NS, Wang H, Das SK. Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus.Endocrinology. 148(10):4774-85, 2007 【查看主页】

Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation.J Exp Med. 204(9): 2053-61, 2007 【查看主页】

Xie H#, Wang H#, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK and Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.Proc Natl Acad Sci USA. 104(46): 18315-20, 2007 【查看主页】

Wang H#, Xie H#, Sun X, Tranguch S,Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN and Dey SK. Stage-specific integration of maternal and embryonic PPARδ signaling is critical to pregnancy success. J Biol Chem. 282(52): 37770-37782, 2007【查看主页】

Rahman MA, Li M, Li P, Wang H, Dey SK, Das SK. Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization. Dev Biol. 290(1): 105-17, 2006 【查看主页】

Wang H#, Xie H#, Zhang H, Das SK and Dey SK. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus. Genesis. 44(2): 51-56, 2006【查看主页】

Wang H and Dey SK. Roadmap to embryo implantation: Clues from mouse models.Nature Review Genetics. 7 (3): 185-199, 2006 【查看主页】

Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK and  DuBois RN. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J. Exp. Med. 203: 941-951, 2006 【查看主页】

Wang H, Dey SK and Maccarrone M. Jekyll and Hyde: Two faces of cannabinoid signaling in male and female fertility. Endocrine Review. 27 (5): 427-448, 2006 【查看主页】

Wang H, Xie H and Dey SK. Endocannabinoid signaling directs periimplantation events.AAPS J. 8 (2): E425-E432, 2006 【查看主页】

Lei L, Zhang H, Jin S, Wang F, Fu M, Wang H* and Xia G*. Stage-specific germ-somatic cell interaction directs the primordial folliculogenesis in mouse fetal ovaries. J Cell Physiol. 208: 640-647, 2006 【查看主页】


Ray S, Hou X, Zhou HE, Wang H, Das SK. Bip is a molecular link between the phase-I and phase-II estrogenic responses in uterus. Mol Endocrinol. 20 (8): 1825-1837, 2006【查看主页】

Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest. 116 (8): 2122-2131, 2006 【查看主页】

Rouzer CA, Tranguch S, Wang H, Zhang H, Dey SK, Marnett LJ. Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclooxygenases-1 and -2. Biochem J. 399 (1): 91-99, 2006【查看主页】

Weng Q, Wang H, Medan MS, Jin W, Xia G, Watanabe G, Taya K. Expression of Inhibin/Activin Subunits in the Ovaries of Fetal and Neonatal Mice.J Reprod Dev.52 (5): 607-616, 2006 【查看主页】

Takahashi T, Morrow JD, Wang H and Dey SK. Cyclooxygenase-2 derived prostaglandin E2 directs oocyte maturation by differentially influencing multiple signaling pathways. J Biol Chem.  281 (48): 37117-37129, 2006 【查看主页】

Anning PB, Coles B, Morton J, Wang H, Uddin J, Morrow JD, Dey SK, Marnett LJ, O'donnell VB. Nitric oxide deficiency promotes vascular side-effects of cyclooxygenase inhibitors in vivo. Blood. 108: 4059-4062, 2006 【查看主页】

Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci USA. 103(50):19069-74, 2006【查看主页】

Guo Y#, Wang H#, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK, Dey SK. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.J Biol Chem.280 (25): 23429-23432, 2005 【查看主页】

Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF and Dey SK. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 02 (40):14326-31, 2005 【查看主页】

Wang H#, Tranguch S#, Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus.Proc Natl Acad Sci USA.102 (28): 9960-9965, 2005 【查看主页】

Tranguch S, Daikoku T, Guo Y, Wang H and Dey SK. Molecular complexity in establishing uterine receptivity and implantation. Cell Mol Life Sci. 62: 1964-73, 2005 【查看主页】

Wang H and Dey SK. Lipid Signaling in Embryo Implantation. Prostaglandins and Other Lipid Mediators. 77: 84-102, 2005 【查看主页】

Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T and Wang H. Molecular Cues to Implantation. Endocrine Review. 25(3): 341-373, 2004 【查看主页】

Matsumoto H, Daikoku T, Wang H, Sato E, Dey SK. Differential expression of Ezrin/Radixin/Moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation. Biol Reprod. 70: 729-736, 2004【查看主页】

Wang H, Ma W, Tejada L, Zhang H, Morrow JD, Das SK, and Dey SK. Rescue of female infertility from the loss of Cyclooxygenase-2 by compensatory upregulation of Cyclooxygenase-1 is a function of genetic make-up. J Biol Chem. 279: 10649-10658, 2004 【查看主页】

Hamatani T, Daikoku T, Wang H, Matsumoto H, Carter MG, Ko MS and Dey SK. Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.Proc Natl Acad Sci USA. 101(28): 10326-10331, 2004 【查看主页】

Gupta RA, Wang D, Katkuri S, Wang H, Dey SK and DuBois RN. Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor- accelerates intestinal adenoma growth. Nature Medicine.10 (3): 245-247, 2004 【查看主页】

Rouzer CA, Kingsley PJ, Wang H, Zhang H, Morrow JD, Dey SK and Marnett LJ. Cyclooxygenase-1-dependent prostaglandin synthesis modulates Tumor Necrosis Factor-α secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. J Biol Chem. 279: 34256-34268, 2004【查看主页】

Medan MS, Wang H, Watanabe G, Suzuki AK and Taya K. Immunization against endogenous inhibin increases normal oocyte/embryo production in adult mice.Endocrine. 24: 115-20, 2004 【查看主页】

Andrews GK, Wang H, Dey SK and Palmiter RD. Mouse Zinc Transporter 1 gene provides an essential function during early embryonic development.Genesis.40: 74-81, 2004【查看主页】

Wang D, Wang H, Shi Q, Katkuri S,Walhi W, Desvergne B, Das SK, Dey SK and DuBois RN. Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor . Cancer Cell. 6: 285-295, 2004【查看主页 】

Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK,DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nature Medicine.10: 1074-1080, 2004 【查看主页】

Yue L, Daikoku T, Hou X, Li M, Wang H, Noji H, Dey SK, DAS SK. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: Evidence for aberrant regulation with Hoxa-10 deficiency.Endocrinology. 146: 2424-2433, 2004 (<https://doi.org/10.1210/en.2004-1605>)

Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res.65(5): 1822-9, 2004 【查看主页 】

Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci USA. 100(25): 14914-14919, 2003 【查看主页】

Paria BC, Wang H, and Dey SK. Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation.Chem Phys Lipids. 121(1-2): 201-210, 2002 【查看主页】

Wang X, Wang H, Matsumoto H, Roy SK, Das SK, and Paria BC. Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster.Development. 129: 4125-4134, 2002 【查看主页】

Wang H, Herath CB, Xia GL, Watanabe G, and Taya K.   Superovulation, fertilization and in vitro embryo development in the mouse after administration of inhibin-neutralizing antiserum. Reproduction. 122: 809-816, 2001 【查看主页】