厦门大学化学化工学院化学生物学系导师介绍：高锦豪

  高锦豪
  高锦豪/Jinhao Gao
  教授、博士生导师
  电话：86-592-2180278
  传真：86-592-2189959
  办公室：卢嘉锡楼528室
  电子邮箱：jhgao@xmu.edu.cn
  课题组网站：http://chem.xmu.edu.cn/group/jhgao/
  个人简历：
  学士（南京大学 2004）
  博士（香港科技大学 2008）
  博士后（斯坦福大学 2010）
  教授（厦门大学 2010.6-）
  香港青年科学家奖 (2007)，教育部“新世纪优秀人才支持计划”（2010），福建省“闽江学者”特聘教授（2011），国家基金委优秀青年科学基金项目资助（2012），福建省杰出青年科学基金资助（2012），福建省青年拔尖创新人才（2014），中国化学会青年化学奖（2014），霍英东教育基金会青年教师奖（2016）
  研究兴趣：
  生物功能分子和纳米颗粒的设计合成及其生物医学应用研究：分子探针，体外诊断，分子影像及成像分析，药物输送，肿瘤诊断治疗，生物纳米技术。
  近期主要代表论著：
  (1) Yang, L.; Wang, Z.; Ma, L.; Li, A.; Xin, J.; Wei, R.; Lin, H.; Wang, R.; Chen, Z.; Gao, J. H.* The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. ACS Nano 2018, DOI: 10.1021/acsnano.1028b01048
  (2) Yang, L.; Ma, L.; Xin, J.; Li, A.; Sun, C.; Wei, R.; Ren, B. W.; Chen, Z.; Lin, H.; Gao, J. H.* Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability. Chem. Mater. 2017, 29, 3038-3047.
  (3) Zhu, X.; Lin, H.; Wang, L.; Tang, X.; Ma, L.; Chen, Z.; Gao, J. H.* Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease 2. ACS Appl. Mater. Interfaces 2017, 9, 21688-21696.
  (4) Zhao, Z. H.; Chi, X. Q.; Yang, L. J.; Yang, R.; Ren, B. W.; Zhu, X. L.; Zhang, P.; Gao, J. H.* Cation Exchange of Anisotropic-Shaped Magnetite Nanoparticles Generates High-Relaxivity Contrast Agents for Liver Tumor Imaging. Chem. Mater. 2016, 28, 3497-3506.
  (5) Zhou, Z. J.; Wu, C. Q.; Liu, H. Y.; Zhu, X. L.; Zhao, Z. H.; Wang, L. R.;  Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.
  (6) Zhao, Z. H.; Wang, X. M.; Zhang, Z. J.; Zhang, H.; Liu, H. Y.; Zhu, X. L.; Li, H.; Chi, X. Q.; Yin, Z. Y.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging. ACS Nano 2015, 9, 2749-2759.
  (7) Zhu, X.; Chi, X.; Chen, J.; Wang, L.; Wang, X.; Chen, Z.; Gao, J. H.* Real-Time Monitoring in Vivo Behaviors of Theranostic Nanoparticles by Contrast-Enhanced T1 Imaging. Anal. Chem. 2015, 87, 8941-8948.
  (8) Wang, L. R.; Zhu, X. L.; Tang, X. Y.; Wu, C. Q.; Zhou, Z. J.; Sun, C. J.; Deng, S. L.; Ai, H.;  Gao, J. H.* A Multiple Gadolinium Complexes Decorated Fullerene as a Highly Sensitive T1 Contrast Agent. Chem. Commun. 2015, 51, 4390-4393.
  (9) Zhou, Z. J.; Zhu, X.; Wu, D.; Chen, Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K.; Gao, J. H.*  Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Chem. Mater. 2015, 27, 3505-3515.
  (10) Zhu, X. L.; Hu, J; Zhao, Z. H.; Sun, M. J.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Kinetic and Sensitive Analysis of Tyrosinase Activity Using Electron Transfer Complexes: In Vitro and Intracellular Study. Small 2015, 11, 862-870.
  (11) Huang, G. M.; Li, H; Chen, J. H.; Zhao, Z. H.; Yang, L. J.; Chi, X. Q.; Chen, Z.; Wang, X. M.; Gao, J. H.* Tunable T1 and T2 Contrast Abilities of Manganese-engineered Iron Oxide Nanoparticles through Size Control. Nanoscale 2014, 6, 10404-10412.
  (12) Zhou, Z. J.; Zhao, Z. H.; Zhang, H.; Wang, Z. Y.;  Chen, X. Y.; Wang, R. F.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.
  (13) Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z.; Hu, J.; Chi, X.; Ni, K.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-performance T2 Contrast Agents for Magnetic Resonance Imaging. Nature Commun. 2013, 4, 2266.
  (14) Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhan, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-oxide-based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.
  (15) Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.
  (16) Chi, X. Q.; Huang, D.T.; Zhao, Z. H.; Zhou, Z. J.; Yin, Z. Y.; Gao, J. H.* Nanoprobes for In Vitro Diagnostics of Cancer and Infectious Diseases. Biomaterials 2012, 33, 189-206.
  (17) Gao, J. H.; Chen, K.; Luong, R.; Bouley, D. M.; Mao, H.; Qiao, T.; Gambhir, S. S.; Cheng, Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Lett. 2012, 12, 281-286.
  (18) Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.
  (19) Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.
  (20) Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.
  (21) Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.
  (22) Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.
  (23) Gao, J. H.; Li, L. H.; Ho, P. L.; Mak, G. C.; Gu, H. W.; Xu, B.* Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood. Adv. Mater. 2006, 18, 3145-3148.
  (24) Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.* Magnetic Dipolar Interaction Induced Self-Assembly Affords Wires of Cobalt Selenide Hollow Nanoscrystals. Angew. Chem. Int. Ed. 2006, 45, 1220-1223.