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华侨大学生物医学学院/医学院导师简介:蔡双凤

作者:聚创华大考研网-余老师 点击量: 1598 发布时间: 2018-09-11 20:59 【微信号:扫码加咨询】

热门关键词:华侨大学生物医学学院/医学院导师  华侨大学蔡双凤  硕士研究生导师


蔡双凤,讲师,硕士生导师

邮箱:caisf@hqu.edu.cn

教育经历:

2007/09-2015/01,中国科学院,微生物研究所,遗传学专业,博士,

2003/09-2007/07,北京大学,生命科学学院,生物科学专业,学士

科研与学术工作经历:

2015/03-至今,华侨大学,生物医学学院,讲师。

研究方向:

生物医学材料开发与应用,海洋生物活性蛋白研究

主持或参加科研项目(课题)及人才计划项目情况:

1. 国家自然科学基青年项目,31700071,基于嗜盐古菌phaP/phaR重组表达的PHA颗粒粒径控制研究,2018/01-2020/1222万元,在研,主持。

2. 福建省青年科技人才创新项目,2017J05052,海洋星虫纤溶酶的表达体系及溶栓机制研究,2017/4-2020/44万元,在研,主持。

3. 华侨大学科研启动费项目-引进人才类(NO. 15BS414),海洋星虫纤溶酶的表达水平检测及其高效表达系统的建立,2015/11-2018/114万元,在研,主持。

4. 福建省海洋经济创新发展区域示范项目,2014FJPT08,台湾海峡海洋抗血栓纤溶酶基因库,2014/01-2016/121350万,在研,参加。

5. 国家自然科学基金重点项目,31330001,极端嗜盐古菌固碳贮碳及其代谢新途径研究,2014/01-2018/12302万元,在研,参加。

代表性研究成果:

第一或通讯作者:

(1) Cai, Shuangfeng(#)Cai, LeiLiu, HailongLiu, XiaoqingHan, JingZhou, JianXiang, HuaIdentification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei.Appl Environ Microbiol2012.3.01786):1946~1952 (被引41次)

(2) Cai, Shuangfeng(#)Cai, LeiZhao, DaheLiu, GuimingHan, JingZhou, JianXiang, Hua(*)A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei.Appl Environ Microbiol2015.1.01811):373~385

(3) 高三星(#),蔡双凤(*),许瑞安,腺相关病毒介导的肝细胞癌靶向治疗策略,药学学报,2017.529):1359-1365

主要参与完成:

(1) Liu, Guiming(#)Cai, ShuangfengHou, JingZhao, DaheHan, JingZhou, JianXiang, HuaEnoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei.Sci Rep2016.4.7624015~24015

(2) Cai, Lei(#)Cai, ShuangfengZhao, DaheWu, JinhuaWang, LeiLiu, XiaoqingLi, MingHou, JingZhou, JianLiu, JingfangHan, JingXiang, HuaAnalysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.Appl Environ Microbiol2014.2.01804):1430~1440

(3) Yang, Haibo(#)Wu, ZhenfangLiu, JingfangLiu, XiaoqingWang, LeiCai, ShuangfengXiang, HuaActivation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins.Nat Commun2015.01.0168321~8321

(4) Liu, Guiming(#)Hou, JingCai, ShuangfengZhao, DaheCai, LeiHan, JingZhou, JianXiang, Hua(*)A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA.Appl Environ Microbiol2015.5.1819):3029~3038

(5) Wul, Jinhua(#)Cai, ShuangfengLiu, HailongHou, JingHan, JingZhou, JianHua, Xiang[Development of PhaP-tagged protein expression and purification systems for extremely halophilic archaea ].Acta Microbiologica Sinica2014.9.4549):998~1009

(6) Cai, Lei(#)Zhao, DaHeHou, JingWu, JinHuaCai, ShuangFengDassarma, PriyaXiang, HuaCellular and organellar membrane-associated proteins in haloarchaea: perspectives on the physiological significance and biotechnological applications.Sci China Life Sci2012.5.01555):404~414

(7) Liu, Hailong(#)Luo, YuanmingHan, JingWu, JinhuaWu, ZhenfangFeng, DeqinCai, ShuangfengLi, MingLiu, JingfangZhou, JianXiang, HuaProteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations.J Proteome Res2013.3.1123):1300~1315

(8) Han, Jing(#)Hou, JingZhang, FanAi, GuominLi, MingCai, ShuangfengLiu, HailongWang, LeiWang, ZejianZhang, SiliangCai, LeiZhao, DaheZhou, JianXiang, HuaMultiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei.Appl Environ Microbiol2013.5.01799):2922~2931

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