作者:聚创华大考研网-余老师 点击量: 1598 发布时间: 2018-09-11 20:59 【微信号:扫码加咨询】
热门关键词:华侨大学生物医学学院/医学院导师 华侨大学蔡双凤 硕士研究生导师
蔡双凤,讲师,硕士生导师
邮箱:caisf@hqu.edu.cn
教育经历:
2007/09-2015/01,中国科学院,微生物研究所,遗传学专业,博士,
2003/09-2007/07,北京大学,生命科学学院,生物科学专业,学士
科研与学术工作经历:
2015/03-至今,华侨大学,生物医学学院,讲师。
研究方向:
生物医学材料开发与应用,海洋生物活性蛋白研究
主持或参加科研项目(课题)及人才计划项目情况:
1. 国家自然科学基青年项目,31700071,基于嗜盐古菌phaP/phaR重组表达的PHA颗粒粒径控制研究,2018/01-2020/12,22万元,在研,主持。
2. 福建省青年科技人才创新项目,2017J05052,海洋星虫纤溶酶的表达体系及溶栓机制研究,2017/4-2020/4,4万元,在研,主持。
3. 华侨大学科研启动费项目-引进人才类(NO. 15BS414),海洋星虫纤溶酶的表达水平检测及其高效表达系统的建立,2015/11-2018/11,4万元,在研,主持。
4. 福建省海洋经济创新发展区域示范项目,2014FJPT08,台湾海峡海洋抗血栓纤溶酶基因库,2014/01-2016/12,1350万,在研,参加。
5. 国家自然科学基金重点项目,31330001,极端嗜盐古菌固碳贮碳及其代谢新途径研究,2014/01-2018/12,302万元,在研,参加。
代表性研究成果:
第一或通讯作者:
(1) Cai, Shuangfeng(#),Cai, Lei,Liu, Hailong,Liu, Xiaoqing,Han, Jing,Zhou, Jian,Xiang, Hua,Identification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei.,Appl Environ Microbiol,2012.3.01,78(6):1946~1952 (被引41次)
(2) Cai, Shuangfeng(#),Cai, Lei,Zhao, Dahe,Liu, Guiming,Han, Jing,Zhou, Jian,Xiang, Hua(*),A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei.,Appl Environ Microbiol,2015.1.01,81(1):373~385
(3) 高三星(#),蔡双凤(*),许瑞安,腺相关病毒介导的肝细胞癌靶向治疗策略,药学学报,2017.52(9):1359-1365。
主要参与完成:
(1) Liu, Guiming(#),Cai, Shuangfeng,Hou, Jing,Zhao, Dahe,Han, Jing,Zhou, Jian,Xiang, Hua,Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei.,Sci Rep,2016.4.7,6:24015~24015
(2) Cai, Lei(#),Cai, Shuangfeng,Zhao, Dahe,Wu, Jinhua,Wang, Lei,Liu, Xiaoqing,Li, Ming,Hou, Jing,Zhou, Jian,Liu, Jingfang,Han, Jing,Xiang, Hua,Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.,Appl Environ Microbiol,2014.2.01,80(4):1430~1440
(3) Yang, Haibo(#),Wu, Zhenfang,Liu, Jingfang,Liu, Xiaoqing,Wang, Lei,Cai, Shuangfeng,Xiang, Hua,Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins.,Nat Commun,2015.01.01,6:8321~8321
(4) Liu, Guiming(#),Hou, Jing,Cai, Shuangfeng,Zhao, Dahe,Cai, Lei,Han, Jing,Zhou, Jian,Xiang, Hua(*),A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA.,Appl Environ Microbiol,2015.5.1,81(9):3029~3038
(5) Wul, Jinhua(#),Cai, Shuangfeng,Liu, Hailong,Hou, Jing,Han, Jing,Zhou, Jian,Hua, Xiang,[Development of PhaP-tagged protein expression and purification systems for extremely halophilic archaea ].,Acta Microbiologica Sinica,2014.9.4,54(9):998~1009
(6) Cai, Lei(#),Zhao, DaHe,Hou, Jing,Wu, JinHua,Cai, ShuangFeng,Dassarma, Priya,Xiang, Hua,Cellular and organellar membrane-associated proteins in haloarchaea: perspectives on the physiological significance and biotechnological applications.,Sci China Life Sci,2012.5.01,55(5):404~414
(7) Liu, Hailong(#),Luo, Yuanming,Han, Jing,Wu, Jinhua,Wu, Zhenfang,Feng, Deqin,Cai, Shuangfeng,Li, Ming,Liu, Jingfang,Zhou, Jian,Xiang, Hua,Proteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations.,J Proteome Res,2013.3.1,12(3):1300~1315
(8) Han, Jing(#),Hou, Jing,Zhang, Fan,Ai, Guomin,Li, Ming,Cai, Shuangfeng,Liu, Hailong,Wang, Lei,Wang, Zejian,Zhang, Siliang,Cai, Lei,Zhao, Dahe,Zhou, Jian,Xiang, Hua,Multiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei.,Appl Environ Microbiol,2013.5.01,79(9):2922~2931
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