华侨大学生物医学学院/医学院导师简介：刘接卿

热门关键词：华侨大学生物医学学院/医学院导师  华侨大学刘接卿  硕士研究生导师  

 

刘接卿副教授，理学博士，硕士研究生导师，华侨大学生物医学学院药学系主任

联系方式

电话：0595-22690323

邮箱：liujieqing@ hqu.edu.cn

通讯地址：福建省泉州市丰泽区城华北路269号，362021

简历：

教育经历

2006/09-2009/07，首都师范大学，遗传学博士；

2003/09-2006/07，吉林大学，药物化学硕士；

1999/09-2003/07，吉林大学，药学学士。

工作经历

2015/01-至今，华侨大学生物医学学院，副教授；

2013/01-2014/12，中国科学院昆明植物研究所，副研究员；

2012/01-2012/12，中国科学院昆明植物研究所，助理研究员；

2009/08-2011/12，中国科学院昆明植物研究所，博士后，合作导师邱明华研究员。

主要研究方向：

1. 天然资源尤其是中草药中新颖活性成分的提取分离和结构鉴定；

2. 从天然产物中寻找药物先导和候选结构；

3. 具有重要生物活性天然产物的结构修饰和作用机制研究；

4. 天然产物活性分子的分子探针合成及作用靶标研究。

科研成果：

在科研方面一直致力于中草药活性物质基础和相关活性作用机理研究，到目前为止已分离鉴定和活性筛选了500余个化合物，取得了多项天然药物研究成果：从小桐子中筛选出了具有抗肿瘤活性的候选化合物；从闽产灵芝中发现抗过敏活性的芳香杂萜类分子；从“维生素C之王”针叶樱桃中发现具有抑制AChE活性的新颖结构等。基本阐明抑制前列腺癌增殖和转移的候选药物CurA的分子作用机制和靶标确证工作，正进行临床前药学其他方面的研究工作；已发现对乳腺癌具有良好抑制作用的天然先导化合物分子JQ222，正进行构效关系和作用机制研究。已在天然产物化学和食品化学领域如Organic Letters, Phytochemistry, PlantaMedica, Tetrahedron, Journal of Agricultural and Food Chemistry, Food Chemistry等国际杂志上发表和参与发表SCI论文30余篇。

承担参与科研项目情况：

1. 在研课题：

1）国家自然科学基金面上项目，靶向抑制RhoA蛋白的二萜化合物curcusone A的抗肿瘤构效关系、结构优化和分子机制研究，主持，62万，2018.01-2021.12；2）横向课题，淫羊藿次苷Ⅱ提取小试工艺开发及化学合成工艺开发，主持，50万，2017.6-2019.6；

3）福建省高校青年自然基金重点项目，龙血树叶辅助降血糖保健品的前期基础研究，主持，10万，2016.12-2019.12；

4）泉州市高端海洋人才资助项目，多色鲜花紫菜饮料和降血压功能紫菜饮料的研究开发，主持，10万，2016.6-2019.6；

5）中央高校基本科研业务费，傣药摆埋嘎筛抗糖尿病活性成分及作用机制研究，主持，40万，2015.11-2019.11；

6）华侨大学科研启动基金，假酸浆生物活性物质基础研究，主持，7万，2015.03-2018.03。

2. 完结课题：

1）国家自然科学基金委，运用结构修饰和构建含氮二萜类似物库的方法挖掘麻疯树植物中抗肿瘤活性成分，主持，23万，2013.01-2015.12；

2）国家自然科学基金委，中药灵芝中化学成分的再认识和保肝抗肝癌生物活性评价，参与，62万，2012.01-2015.12；

3）院地合作，蓝莓花青素高效提取技术与中试应用，参与，50万，2012.01-2015.12；

4国际合作，合作研究分析安利功能植物化学成分，参与，100万，2012.01-2015.12。

获奖及荣誉：

2014年01月入选第十六批云南省中青年学术和技术带头人后备人才；

2014年11月入选龙岩市首批创新人才；

2017年10月入选泉州市第四层次人才。

代表论著：

1.      Xiao, Q.; Wang, C.-F.; Chen, J.; Lian, C.-L.; Xu, Y.; Xiao, L.; Liu, J.-Q.*, Three new withanolides from the calyces of Nicandra physaloides. Steroids 2018, 131, 32-36

2.      Yu, M.-Y.1; Zhao, G.-T.1; Liu, J.-Q.1; Khan, A.; Peng, X.-R.; Zhou, L.; Dong, J.-R.; Li, H.-Z.; Qiu, M.-H., Withanolides from aerial parts of Nicandra physalodes. Phytochemistry 2017, 137, 148-155.

3.      Lian, C.-L.; Wang, C.-F.; Xiao, Q.; Xiao, L.; Xu, Y.; Liu, J.-Q.*, The triterpenes and steroids from the fruiting body Ganoderma duripora. Biochemical Systematics and Ecology 2017, 73, 50-53.

4.      Lian, C.-L.; Wu, Y.-Q.; Chen, T.-Q.; Liu, X.-Q.; Cong, H.; Xiao, L.; Xu, Y.; Liu, J.-Q.*, Identification of new trace triterpenoids from the fungus Ganoderma duripora. Phytochemistry Letters 2017, 21, 237-239.

5.      Liu, J.-Q.; Yang, Y.-F.; J.-J; Li, X.-Y;Li,Z.-R; Zhou, L.;Qiu, M.-H*. Cytotoxic diterpenoids from Jatrophacurcas cv. Nigroviensrugosus CY Yang roots. Phytochemistry, 117, 462‒468, 2015.

6.      Liu, J.-Q.; Deng, Y.-Y.1; Li, Y.; Li, T.-Z.; Han, Q.;Qiu, M.-H.*, Three New Tetranorditerpenes from Aerial Parts of Acerola Cherry (Malpighiaemarginata). Molecules, 19 (2), 2629-36, 2014.

7.      Li X.-Y, Yang Y.-F, Peng X.-R, Li M.-M, Li L.-Q, Deng X, Qin H.-B*, Liu J.-Q*, Qiu M.-H*. One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B. Organic Letters, 12(8),2196-2199, 2014.

8.      Liu, J.-Q.; Yang, Y.-F.1; Li, X.-Y.; Liu, E.-Q.; Li, Z.-R.; Zhou, L.; Li, Y.; Qiu, M.-H.*,Cytotoxicity of naturally occurring rhamnofolanediterpenes from Jatrophacurcas.Phytochemistry (Elsevier), 96, 265-272, 2013.

9.      Liu, J.-Q.; Peng, X.-R.; Zhang, W.-M.; Shi, L.; Li, X.-Y.; Chen, J.-C.; Qiu, M.-H.*,Swietemahalactone, a rearranged phragmalin-type limonoid with anti-bacterial effect, fromSwieteniamahagoni. RSC Advances, 3, (15), 4890-4893, 2013.

10.  Liu, J.-Q.; Peng, X.-R.; Li, X.-Y.; Li, T.-Z.; Zhang, W.-M.; Shi, L.; Han, J.; Qiu,M.-H.*,Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree(Malpighiaemarginata). Organic Letters, 15, (7), 1580-1583, 2013.

11.  Liu, J.-Q.; Yang, Y.-F.; Wang, C.-F.; Li, Y.; Qiu, M.-H.*, Three new diterpenesfromJatrophacurcas. Tetrahedron, 68, (4), 972-976, 2012.

12.  Liu, J.-Q.; Wang, C.-F.; Li, Y.; Luo, H.-R.; Qiu, M.-H.*, Isolation and bioactivityevaluation of terpenoids from the medicinal fungus Ganodermasinense. Planta Medica,78, (4), 368-376, 2012.

13.  Liu, J.-Q.; Wang, C.-F.; Li, Y.; Chen, J.-C.; Zhou, L.; Qiu, M.-H.*, Limonoidsfromthe leaves of Toonaciliata var. yunnanensis. Phytochemistry (Elsevier), 76, 141-149, 2012.

14.  Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Qiu, M.-H.*, Limonoids from the leaves ofSwieteniamacrophylla. Natural Product Research, 26, (20), 1887-1891, 2012.

15.  Liu, J.-Q.; Wang, C.-F.; Peng, X.-R.; Qiu, M.-H.*, New alkaloids from the fruitingbodies of Ganodermasinense. Natural Products and Bioprospecting, 1, (2), 93-96, 2011.

16.  Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Chen, J.-C.; Li, Y.; Qiu, M.-H.*, One newpregnane glycoside from the seeds of cultivated Bruceajavanica. Archives of PharmacalResearch, 34, (8), 1297-1300, 2011.

17.  Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H.*, One new cucurbitanetriterpenoid from the fruits of Momordicacharantia. European Journal of Chemistry, 1, (4), 294-296, 2010.

18.  Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Tu, S.-H.; Gu, H.-F.; Hu, W.-X.; Qiu, M.-H.*, Six New Triterpenoid Glycosides from Gynostemmapentaphyllum. Helvetica ChimicaActa 92, (12), 2737-2745, 2009.

19.  Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H., New cucurbitanetriterpenoids and steroidal glycoside from Momordicacharantia. Molecules 14, (12), 4804-4813, 2009.

20.  Sun, A.-J.; Liu, J.-Q.; Pang, S.-Q.; Lin, J.; Xu, R.-A., Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata. Bioorganic & Medicinal Chemistry Letters 2016,26 (9), 2375-2379.

21.  Peng, X.-R.; Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Shu, Y.; Zhou, L.; Qiu, M.-H.*, Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear. Journal ofNatural Products,77(4), 737-743, 2014.

22.  Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Wang, C.-F.; Li, X.-Y.; Deng, Y.; Bao, N.-M.; Zhang, Z.-R.; Qiu, M.-H.*, Lanostanetriterpenoids from Ganodermahainanense J. D. Zhao. Phytochemistry,114, 137-245, 2014.

23.  Peng, X..-R.; Liu, J.-Q.; Wang, C.-F.; Han, Z.-H.; Shu, Y.; Li, X.-Y.; Zhou, L.; Qiu, M.-H.*, Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear. Food chemistry, 171, 251-257, 2015.

24.  Zhao, G.-T.; Liu, J.-Q.; Deng, Y.-Y.; Li, H.-Z.; Chen, J.-C.; Zhang, Z.-R.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-Type Triterpenoids from the Stems and Leaves of Momordicacharantia. Fitoterapia, 96, 79-82, 2014.

25.  Shu, Y.; Liu, J.-Q.; Peng, X.-R.; Wan, L.-S.; Zhou, L.; Zhang, T.; Qiu, M.-H.*, Characterization of diterpenoidglucosides in roasted Puer coffee bean. Journal of Agricultural and Food Chemistry, 62 (12), 2631–2637, 2014.

26.  Hu, K.; Liu, J.-Q.; Li, X.-N.; Chen, J.-C.; Zhang, W.-M.; Li, Y.; Li, L.-Q.; Guo,L.-L.; Ma, W.-G.; Qiu, M.-H.*, Chukfuransins A-D, Four new phragmalinlimonoids withb-furan ring involved in skeleton reconstruction from Chukrasiatabularis. OrganicLetters, 15, (15), 3902-3905, 2013.

27.  Peng, X.-R.; Liu, J.-Q.; Han, Z.-H.; Yuan, X.-X.; Luo, H.-R.; Qiu, M.-H.*,Protective effects of triterpenoids from Ganodermaresinaceum on H2O2-induced toxicity inHepG2 cells. Food Chemistry, 141, (2), 920-926, 2013.

28.  Wang, H.-W.; Liu, J.-Q.; Chen, J.-X.; Yang, Y.-F.; Yan, Y.-X.; Li, Z.-R.; Qiu,M.-H.*, New triterpenoids from the kernels of Azadirachtaindica. Natural Products andBioprospecting, 3, (1), 33-37, 2013.

29.  Yang, Y. F.; Liu, J. Q.; Li, X. Y.; Liu, E. Q.; Li, Z. R.; Qiu, M. H.*, New terpenoidsfrom the roots of Jatrophacurcas. Chinese Science Bulletin, 58, (10), 1115-1119, 2013.

30.  Yang, Y.-F.; Liu, J.-Q.; Li, Z.-R.; Li, Y.; Qiu, M.-H.*, New eudesmenoicacidmethyl esters from the seed oil of Jatrophacurcas. Fitoterapia, 89, 278-284, 2013.

31.  Yang, Y.-F.; Liu, J.-Q.; Shi, L.; Li, Z.-R.; Qiu, M.-H.*, New jatropholane-typediterpenesfromJatrophacurcas cv. Multiflorum CY Yang. Natural Products andBioprospecting, 3, (3), 99-102, 2013.

32.  Peng, X. R.; Liu, J. Q.; Wan, L. S.; Li, X. N.; Yan, Y. X.; Qiu, M. H.*, Four new polycyclic meroterpenoids from Ganoderma cochlear. Organic letters, 16, (20), 5262-5265, 2014.

33.  Yan, Yu-Xin; Liu, Jie-Qing; Wang, Hong-Wei; Chen, Jin-Xiong; Chen, Jian-Chao; Chen, Li; Zhou, Lin; Qiu, Ming-Hua; Identification and Antifeedant Activities of Limonoids from Azadirachtaindica; Chemistry & Biodiversity (2015), 12(7), 1040-1046.

34.  Peng, XingRong; Liu, JieQing; Wang, CuiFang; Han, ZhongHui; Shu, Yi; Li, XuYang; Zhou, Lin; Qiu, MingHua; Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear; Food Chemistry (2015), 171, 251-257.

35.  Yan, Yu-Xin; Liu, Jie-Qing; Chen, Jin-Xiong; Chen, Jian-Chao; Qiu, Ming-Hua; Three new limonoids from Azadirachtaindica; Journal of Asian Natural Products Research (2015), 17(1), 14-19.

36.  Chen Jian-Chao; Liu Jie-Qing; Zhou Lin; Qiu Ming-Hua; Lau Clara Bik-San; Chan Judy Yuet-Wa; Fung Kwok-Pui; Leung Ping-Chung; Xie Ming-Jin; The antigluconeogenic activity of cucurbitacins from Momordicacharantia; Plantamedica (2015), 81(4), 327-332.

37.  Jiang, S.-Y.; Liu, J.-Q.; Xia, J.-J.; Yan, Y.-X.; Qiu, M.-H.*, Five newtetranortriterpenoids from the seeds of Toonaciliata. Helvetica ChimicaActa, 95, (2),301-307, 2012.

38.  Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Yang, Y.-H.; Qiu, M.-H.*, Two new triterpenoidsfromGanoderma cochlear. Zhongcaoyao, 43, (6), 1045-1049, 2012.

39.  Wang, C.-F.; Liu, J.-Q.; Yan, Y.-X.; Chen, J.-C.; Lu, Y.; Guo, Y.-H.; Qiu, M.-H.*, Three new triterpenoidscontaining four-membered ring from the fruiting body of Ganodermasinense. Organic Letters, 12, (8), 1656-1659, 2010.

40.  Cheng, B.-H.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-typetriterpenoids from Momordicacharantia. Helvetica ChimicaActa, 96, (6), 1111-1120, 2013.

41.  Xu, W.-X.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Wang, Y.-F.; Qiu, M.-H.*, Three newphysalins from Physalisalkekengi var. franchetii. Natural Products and Bioprospecting,3, (3), 103-106, 2013.

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