华侨大学生物医学学院/医学院导师简介：崔秀灵

热门关键词：华侨大学生物医学学院/医学院导师  华侨大学崔秀灵  硕士研究生导师  

 

崔秀灵教授（博导）

E-mail:cuixl@hqu.edu.cn

研究方向  有机化学

教育经历

•  1996-1999，郑州大学，化学系，博士研究生，导师：吴养洁院士

•  1993-1996，郑州大学，化学系，硕士研究生，导师：吴养洁院士

•  1989-1993，郑州大学，化学系，本科

工作经历

•  2010.7-迄今，闽江学者特聘教授

•  1999.7-2010.7，郑州大学，化学系

其中：2000.9-2006.8，葡萄牙新里斯本大学，化学生物技术研究院，博士后

2002年被聘为郑州大学化学系副教授

2008年被聘为郑州大学化学系教授

发表文章情况（近三年发表的部分科技文章）

1. Iodine-Catalyzed Directed C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes, Zhang, Zhenhao; Pi, Chao; Tong, Heng; Wu, Yangjie*; Cui, Xiuling*, Org Lett. 2016, Accepted

2. Iridium-Catalyzed Direct ortho-C–H Amidation of Benzaldehydes through N-Sulfonyl Imines as Mask，Yudong Li，Yadong Feng，Linhua Xu，Lianhui Wang and Xiuling Cui*，Org. Lett., 2016, 18 (19), pp 4924–4927

3. C8-Selective Acylation of Quinoline N-Oxides with α-Oxocarboxylic Acids via Palladium-Catalyzed Regioselective C-H Bond Activation，Xiaopei Chen, Xiuling Cui* and Yangjie Wu*, Org Lett 2016, 3722-3725

4. Access to C4-Functionalized Quinolines via Copper-Catalyzed Tandem Annulation of Alkynyl Imines with Diazo Compounds，Ruifeng Zhu, Guolin Cheng,* Chunqi Jia, Lulu Xue, and Xiuling Cui*，J Org Chem, 2016, 7539.

5. Copper-Catalyzed Oxidative Amination of Quinoxalin-2(1H)-ones with Amines, Yi Li, Ming Gao, Lianhui Wang and Xiuling Cui* Org. Bioorg. Chem. 2016, 8428 cover

6. Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines, Pengfei Li, Yunxiang Weng, Xianxiang Xu, Xiuling Cui*， J. Org. Chem. 2016， 81 (10),  3994–4001

7. One-Pot Regiospecific Synthesis of Quinoxalines via a CH2-Extrusion Reaction, Jinhai Shen, Xiangdong Wang, Xing Lin, Zhenhui Yang, Guolin Cheng, Xiuling Cui* Org Lett, 2016, 18 (6), pp 1378–1381. Highlighted by Synfact in May 2016

8.“One Pot” Approach to 8-Acylated 2-Quinolinones via Pd-Catalyzed Regioselective Acylation of Quinoline N-oxides, Xiaopei Chen, Xiuling Cui* and Yangjie Wu*, Org Lett 2016 18 (10), 2411–2414 hot article

9. Biological evaluation of ferrocenyl olefins: cancer cell growth inhibition, ROS production and apoptosis activity，Aijing Sun, Junsheng Lin, Chao Pi, Ruian Xu, Xiuling Cui,* Archiv der Pharmazie，2016，349(3), 186-192

10. Base-Promoted Synthesis of Multisubstituted Benzo[b][1,4]oxazepines, Jinhai Shen, Lulu Xue, Xing Lin, Guolin Cheng and Xiuling Cui*, Chem Commun. 2016, back cover, 3292-3295.

11. Efficient and Selective Synthesis of (E)-Enamides via Ru(II)-Catalyzed Hydroamidation of Internal Alkynes, Changsheng Kuai, Lianhui Wang, Haoyi Cui, Jinhai Shen, Yadong Feng, Xiuling Cui* ACS Catal, 2016, 186-190

12.     Direct Phosphonation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions，Ming Gao, Yi Li, Lijuan Xie, Xiuling Cui*，Chem Commun, 2016,52,2846 - 2849

13. Ir(III)-Catalyzed Direct C-H Sulfonylamidation of 2-Aryl-1,2,3-Triazole N-oxides with Sulfonyl Azides, Bingfeng Zhu, Xiuling Cui*, Chao Pi, Dong Chen, Yangjie Wu,* Adv Synth Catal, 2016, 326-332.

14. Rhodium(III)-Catalyzed C−H Activation/Alkyne Annulation by Weak Coordination of Peresters with O−O Bond as an Internal Oxidant, Jiayu Mo, Lianhui Wang, Xiuling Cui*, Org Lett, 2015, 17, 4960-4963.

15.     Iridium-Catalyzed Direct C-H Sulfamidation of Arylnitrones with Sulfonyl Azides at Room Temperature，Chao Pi, Xiuling Cui*, Yangjie Wu*，J Org Chem，2015, 7333-7339 Selected as a Feature article

16.     Base-Promoted N-Pyridylation of Heteroarenes Using N-Propargyl Enaminones as Equivalents of Pyridine Scaffolds，Guolin Cheng,* Yunxiang Weng, Xifa Yang, and Xiuling Cui*，Org Lett, 2015, 3790-3793

17.     Palladium-Catalyzed Direct ortho C-O Bond Construction of Azoxybenzenes with Carboxylic Acids and Alcohols, Duo Zhang, Xiuling Cui*, Fangfang Yang, Qianqian Zhang, Yu Zhu, and Yangjie Wu*  Org. Chem. Front., 2015,  2015, 2, 951 – 955

18.     Copper-Catalyzed Synthesis of Quinazolinones from Indoles with Amines or Ammoniums, Feng, Yadong; Li, Yudong; Cheng, Guolin; Wang, Lianhui; Cui, Xiuling,* J. Org Chem, 2015, 80 (14), pp 7099–7107

19.     Base Promoted Cross Dehydrogenative Coupling of Quinoline N-Oxides with 1,3-Azoles",  Chen, Xiaopei; Cui, Xiuling;* Yang, Fangfang; Wu, Yangjie,* Org Lett, 2015 1445.

20.     Base-promoted β-C(sp3)-H functionalization of enaminones: an approach to polysubstituted pyridines，Shen, Jinhai; Cai, Dingding; Kuai, Changsheng; Liu, Yunqi; Wei, Ming'e; Cheng, Guolin; Cui, Xiuling*，J. Org Chem, 2015, 6584-6589.

21.     Redox Tuning Asymmetric Aldol Reaction，Qiying Zhang, Xiuling Cui,* Long Zhang, Sanzhong Luo,* Hui Wang and Yangjie Wu* Angew. Chem. Int. Ed. 2015, 5210

22.     Cleavage of the C-C Triple Bond of the Ketoalkynes: Synthesis of 4(3H)-Quinazolinones Xifa Yang, Guolin Cheng, Jinhai Shen, Changsheng Kuai, Xiuling Cui* Org. Chem. Front., 2015，2, 366

23.     Transition-Metal-Catalyzed Direct C–H Functiona-lization under External-Oxidant-Free Conditions, Jiayu Mo, Lianhui Wang, Yunqi Liu, Xiuling Cui*, Synthesis, 2015, 47，439-459， invited review.

24.     Pd-catalyzed Direct C-H Bond Sulfonylation of Azobenzenes with Arylsulfonyl Chlorides, Zhang Duo; Cui Xiuling, * Zhang Qianqian; Wu Yangjie,* J Org Chem 2015, 1517-1522

25.     Directly Regioselective Phosphonation of Heteroaryl N-oxides with H-phosphonates under Metal and External Oxidant Free Conditions, Hui Wang, Xiuling Cui*, Yu Pei, Qianqian Zhang, Jie Bai, Donghui Wei and Yangjie Wu*, Chem Commun,  2014， 50（92），14409-14411.

26.     Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-catalyzed Enantioselective C-H Bond Activation, Chao Pi, Xiuling Cui,* Xiuyan Liu, Mengxing Guo, Hanyu Zhang and Yangjie Wu* Org Lett, 2014, 16（19），5164-5167

27.     Copper-Catalyzed One-Pot Synthesis of Unsymmetrical Arylurea Derivatives via Tandem Reaction of Diaryliodonium Salts with N-Arylcyanamide, Pengfei Li, Guolin Cheng*, Hong Zhang, Xianxiang Xu, Jingyuan Gao, Xiuling Cui*  J Org Chem 2014, 8156-8162

28.     A metal-free synthesis of diaryl-1,2-diketones by C–C triple bond cleavage of alkynones, Xuesong Wang, Guolin Cheng, Jinhai Shen, Xifa Yang, Ming-e Wei, Yadong Feng and Xiuling Cui*, Org. Chem. Front., 2014, 1, 1001-1004.

29.     Copper-catalyzed Reductive Coupling of Aryl Sulfonyl Chlorides with H-Phosphonates Leading to S-Aryl Phosphorothioates, Jie Bai, Xiuling Cui,* Hui Wang, and Yangjie Wu* Chem Commun, 2014 8860-8863

30.     Copper-catalyzed Direct Amination of Quinoline N-Oxides via C-H Bond Activation under Mild Conditions, Chongwei Zhu, Meiling Yi, Donghui Wei, Xuan Chen , Yangjie Wu*, Xiuling Cui* Org Lett, 2014，pp 1840–1843

31.     Palladium(II)-catalyzed Direct Regioselectively Oxidative Acylation of Azobenzenes with Toluene Derivatives, Hongyu Song,  Dong Chen, Chao Pi, Xiuling Cui, * Yangjie Wu, * J Org Chem 2014，79 (7), pp 2955–2962

32.     Tandem Synthesis of 3-Ally-chromones from Alkynones and Allylic Alcohols under Metal-free Conditions, Xuesong Wang, Guolin Cheng, Xiuling Cui*, Chem Commun 2014, 50(6), 652-654 DOI:10.1039/C3CC48259F.

33.     A Metal-free Multicomponent Cascade Reaction for the Regiospecific Synthesis of 1,5-Disubstituted 1,2,3-Triazoles, Guolin Cheng, Xiaobao Zeng, Jinhai Sheng, Xuesong Wang, and Xiuling Cui*, Angew. Chem. Int. Ed. 2013, 13265-13268

34.     “One pot” regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions, Jinhai Shen, Guolin Cheng, Xiuling Cui*, Chem. Comm. 2013, 49 (90), 10641 – 10643.

35.     Direct 2-acetoxylation of Quinoline N-oxides via Copper Catalyzed C-H bond Activation, Xuan Chen, Chongwei Zhu, Xiuling Cui* and Yangjie Wu*, Chem. Comm. 2013, 6900-6902.

36.     Palladium-Catalyzed Oxidative Cross-Coupling of N-Tosylhydrazones with Indoles: Synthesis of N-Vinylindoles, Xiaobao, Zeng, Guolin Cheng, Jinhai, Shen, Xiuling Cui*, Org. Lett. 2013, 3022-3025.

37.     Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C-H bonds activation，Chao Pi, Ying Li, Xiuling Cui*, Hao Zhang, Yanbing Han and Yangjie Wu*，Chem Sci., 2013 2675-2679. The most accessed papers in April, 2013. Synfact in Sep. 2013

38.     Sulfonylation of quinoline-N-oxides with aryl sulfonyl chlorides via copper-catalyzed C-H bonds activation, Zhiyong Wu, Hongyu Song, Xiuling Cui*, Chao Pi, Weiwei Du, Yangjie Wu*, Org. Lett., 2013, 1270-1273

39.     Efficient Approach to 4-Sulfonamidoquinolines via Copper(I)-catalyzed Cascade Reaction of Sulfonyl Azides with Alkynyl Imines, Guolin Cheng, Xiuling Cui*, Org. Lett., 2013, 15(7), 1480-1483.

40.     Direct C2-Alkylation of Quinoline N-oxides with Ethers via Palladium-catalyzed Dehydrogenative Cross-coupling Reaction, Zhiyong Wu, Chao Pi, Xiuling Cui,* Jie Bai, and Yangjie Wu*, Adv Synth & Cat, 2013, 1971-1976.

承担项目情况

无外加氧化剂的C-H键官能团化反应研究（21572072），国家自然科学基金面上项目，78万。

厦门市海洋小分子药物中间体与蛋白质纳米配方创新协同中心（15PYY052SF01），国家海洋公益项目，500万。

医药中间体或天然产物中一些杂环化合物的绿色构筑（3502Z20150054），厦门市科技局，75万。

海洋抗乙肝抗病毒药物研发（13GYY003NF16），国家海洋公益项目， 312.39万。

基因治疗关键技术及产品研发（2012AA020810），国家863计划，88万。

福建省闽江学者支持计划，福建省特聘教授（10BS216），200万。

手性胺配体的设计合成及其在药物合成方面的应用研究（3502z20101014），厦门市科技局，30万。

授权专利情况

崔秀灵，王富源，一种1,3,5-三芳基苯化合物的合成方法，2016.11.30, 中国，ZL201510399940.7

崔秀灵，白洁等一种S-芳基硫代磷酸酯的制备方法，2016.3.2，中国，ZL201410005384.6

崔秀灵，林锋等，一种苯并二氧杂己烯酮芳香化合物的合成方法，2015.8.5，中国，ZL201310726367.7

崔秀灵，王连会等，二茂铁亚胺环钯-膦加合物在不对称联芳化合物合成中的应用，2012.9.5, 中国，ZL201110022668.2

崔秀灵，马骥，二茂铁咪唑啉环钯化合物、其制备以及在催化合成偶联产物方面的应用, 2009.5.27, ZL200710053932.2

崔秀灵，皮超，硝酮取代磺酰芳香胺类衍生物及其制备方法, ZL201510194413.2

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