厦门大学生命科学学院导师介绍：韩爱东

  韩爱东HAN Aidong, Ph.D.
  韩爱东教授
  教授,博士生导师
  电 话：+86-592-2188172
  E-mail: ahan@xmu.edu.cn
  homepage: www.aidonghanlab.com/
  1985年9月－1989年7月, 南京大学/生物系, 学士学位
  1992年9月－1995年7月, 中山大学/遗传工程中心, 硕士学位
  1995年5月－1999年8月, 中国科学学院微生物研究所,博士学位
  1999年9月－2006年5月，美国科罗拉多大学博德分校/生化系, 访问学者
  2006年6月－2008年1月，美国南加州大学/分子与计算生物系, 访问学者
  1999, Ph.D., Institute of Microbiology, Chinese Academy of Sciences; 1999-2006, Postdoctoral follow, University of Colorado at Boulder; 2006-2008, Senior research associate, University of Southern California.
  研究领域（Research Area)
  核细胞中，转录因子与特异的增强子结合并进一步形成巨大的复合体以调节转录的水平。这些转录因子进一步和各种辅因子相互作用，有效地调节细胞的编程和重编程。我们在解析转录因子与其辅因子复合体结构(图1）的基础上进一步研究其它表观遗传的因子，特别是负责组蛋白乙酰化的蛋白在转录调控过程中的作用机制。
  原核细胞中，组氨酸激酶（sensor histidine kinase，SK）负责刺激依赖的磷酸化并将信号转导至调节蛋白（response regulator，RR)，以调控相应的生物学过程，包括基因的转录。这一调控系统被称作双组分系统（Two-Component System，TCS），是原核细胞的主要的应急调控系统。VicRK是肺炎等疾病的致病链球菌中生死攸关的TCS。VicK带有传导或感应的元件HAMP和PAS，负责对各种刺激作出反应，并调节VicR介导的应急性基因的转录。我们从解析VicK的晶体结构开始，从结构和功能关系上探讨HAMP和PAS如何将信号从刺激传导到激酶的分子机制。我们还将以该结构为基础积极研制新的抗菌素来对付耐药性的细菌的感染。

  Transcription is a key step for gene expression regulation, which in turn globally programs or reprograms the cells. In prokaryotic cells, two-component system (TCS), including histidine kinase (SK) and response regulator (RR), is responsible for stimuli induced transcription. Our lab uses VicRK, one of streptococci TCS as a model system to understand how the intra/extracellular signals regulate the transcription of bacteria. In eukaryote cells, transcription factors as well as cofactors are centered on the specific enhancer regions of genes to form high-order regulatory assemblies. The most, if not all, of these cofactors are histone modification enzymes that convey a variety of upstream signals to epigenetic marks. Our lab is taking a structural and functional approach to understand molecular mechanisms of the epigenetic modifications and transcriptional regulation, in particular the histone acetylation by p300, CBP and PCAF.

  代表性论文(Selected Publications)
  1.Wang C; Sang JY; Wang JW; Su MY; Downey JS; Wu QG; Wang SD; Cai YF; Xu XZ; Wu J; Senadheera DB; Cvitkovitch DG; Chen L; Goodman SD; Han AD.Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains. PLOS BIOLOGY 11(2):e1001493 (2013)
  2.Jayathilaka N; Han AD; Gaffney KJ; Dey R; Jarusiewicz JA; Noridomi K; Philips MA; Lei X; He J; Ye J; Gao T; Petasis NA; Chen L. Inhibition of the funcation of class Iia HDACs by blocking their interaction with MEF2. Nucleic Acid Research 40(12):5378-88 (2012)
  3.Mao YJ; Lin JY; Zhou AB; Ji KM; Downey JS; Chen RC; Han AD. Quikgene:a gene synthesis method integrated with ligation free cloning. ANALYTICAL BIOCHEMISTRY 415(1):21-26 (2011)
  He J; Ye J; Cai YF; Riquelme C; Liu JO; Liu XD; Han AD; Chen L.Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. NUCLEIC ACIDS RESEARCH 39(10):4464-4474 (2011)
  4.Wu YQ; Dey R; Han AD; Jayathilake N; Philips M; Ye J; Chen L. Structure of the MADS-box/MEF2 domain of MEF2 bound to DNA and its implication for myocardin recruitment. Journal of Molecular Biology 397(2):520-533 (2010)
  5.Guo L, Han A, Bates DL. Cao J, Chen L. Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains. Proceedings of the National Academy of Sciences USA 104(11): 4297-4302 (2007)
  6.Han A, He J, Wu Y, Liu JO, Chen L. Mechanism of recuitment of class II histone deacetylases by Myocyte enhancer factor-2. Journal of Molecular Biology 345(1):91-102 (2005)
  7.Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by Myocyte Enhancer Factor-2. Nature 422(6933): 730-734 (2003)
  参加学术团体的情况（Professional service）
  中国生物化学和分子生物学会会员
  中国生物物理学会会员
  美国心脏和中风学会会员