厦门大学医学院导师介绍：陈杰

陈杰
职称： 副教授/硕导
学科（方向）：免疫学
所在系部：基础医学部
办公电话：0592-2186335
邮    箱：jiechen86213@163.com
研究领域：
研究固有免疫相关分子、细胞的功能及相互作用机理，并探究其对免疫相关疾病的发病和进展的作用，从而为疾病的预防及治疗提供实验依据。
学习经历：
2009~2012华中科技大学同济医学院免疫学专业，医学博士；
2007~2009华中科技大学同济医学院免疫学专业，医学硕士；
2003~2007华中科技大学同济医学院生物药学专业，理学学士。
工作经历：
2012~2016  厦门大学医学院  助理教授；
2016~至今厦门大学医学院  副教授。
代表性成果：
1. Jie Chen, Lihua Duan, Ali Xiong, Hongwei Zhang, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice, J Mol Med, 2012, 90(12): 1505-1515
2. Tu Lei, Chen J, Zhang H,Duan L.Interleukin-4 Inhibits Regulatory T Cell Differentiation through Regulating CD103+ Dendritic Cells. Front Immunol. 2017 Mar 3;8:214. (co-first author)
3. Tu Lei, Chen J,Xu D, Xie Z, Yu B, Tao Y, Shi G,Duan L.IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis. Oncotarget. 2017 Apr 25;8(17):27704-27714. (co-first author)
4.  Lihua Duan#, Jie Chen#, Quansong Xia, Liying Chen, Kai Fan, K.R. Sigdel, Min Fang, Fang Zheng, Guixiu Shi*, Feili Gong*, IL-17 promotes Type 1 T cell response through modulating dendritic cell function in acute allograft rejection, Int Immunopharmacol, 2014, 20(2): 290-297 (co-first author)
5. Lihua Duan#, Jie Chen#, Feili Gong*, Guixiu Shi*, The role of IL-33 in rheumatic diseases, Clin Dev Immunol, 2013(2013): 924363 (co-first author)
6. Lihua Duan#, Jie Chen#, Hongwei Zhang, Heng Yang, Ping Zhu, Ali Xiong, Quansong Xia, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3+ regulatory T-cell responses in mice, Mol Med, 2012, 18(1): 753-761 (co-first author)
7. Dai C, Lu FN, Jin N, Yang B, Gao C, Zhao B, Fu JZ, Hong SF, Liang HT, Chen LH, Chen ZS, Chen J*, Qi ZQ*, Recombinant IL-33 Prolongs Leflunomide-mediated Graft Survival by Reducing IFN-γ and Expanding CD4+Foxp3+ T Cells in Concordant Heart Transplantation, Lab Invest. 2016 Aug;96(8):820-9. (corresponding author)
8. Duan L, Huang Y, Su Q, Lin Q, Liu W, Luo J, Yu B, He Y, Qian H, Liu Y, Chen J*, Shi G*, Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients, J Diabetes Res, 2016;2016:1028401. (corresponding author)
主持过的重要课题：
1.国家自然科学基金青年项目（81301786）IL-33通过诱生Treg促进小鼠乳腺癌发展的作用及机制，2014/01-2016/12，已结题
所有论文列表：
1. Jie Chen, Lihua Duan, Ali Xiong, Hongwei Zhang, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-? production in mice【查看主页】 , J Mol Med, 2012, 90(12): 1505-1515
2. Tu Lei, Chen J, Zhang H,Duan L.Interleukin-4 Inhibits Regulatory T Cell Differentiation through Regulating CD103+ Dendritic Cells 【查看主页】. Front Immunol. 2017 Mar 3;8:214. (co-first author)
3. Tu Lei, Chen J,Xu D, Xie Z, Yu B, Tao Y, Shi G,Duan L.IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis 【查看主页】. Oncotarget. 2017 Apr 25;8(17):27704-27714. (co-first author)
4.  Lihua Duan#, Jie Chen#, Quansong Xia, Liying Chen, Kai Fan, K.R. Sigdel, Min Fang, Fang Zheng, Guixiu Shi*, Feili Gong*, IL-17 promotes Type 1 T cell response through modulating dendritic cell function in acute allograft rejection【查看主页】 , Int Immunopharmacol, 2014, 20(2): 290-297 (co-first author)
5. Lihua Duan#, Jie Chen#, Feili Gong*, Guixiu Shi*, The role of IL-33 in rheumatic diseases 【查看主页】, Clin Dev Immunol, 2013(2013): 924363 (co-first author)
6. Lihua Duan#, Jie Chen#, Hongwei Zhang, Heng Yang, Ping Zhu, Ali Xiong, Quansong Xia, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3+ regulatory T-cell responses in mice 【查看主页】, Mol Med, 2012, 18(1): 753-761 (co-first author)
7. Dai C, Lu FN, Jin N, Yang B, Gao C, Zhao B, Fu JZ, Hong SF, Liang HT, Chen LH, Chen ZS, Chen J*, Qi ZQ*, Recombinant IL-33 Prolongs Leflunomide-mediated Graft Survival by Reducing IFN-? and Expanding CD4+Foxp3+ T Cells in Concordant Heart Transplantation 【查看主页】, Lab Invest. 2016 Aug;96(8):820-9. (corresponding author)
8. Duan L, Huang Y, Su Q, Lin Q, Liu W, Luo J, Yu B, He Y, Qian H, Liu Y, Chen J*, Shi G*, Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients【查看主页】 , J Diabetes Res, 2016;2016:1028401. (corresponding author)
9. Wen Liu <http://www.ncbi.nlm.nih.gov/pubmed/?term=Liu W[auth]>#, Keshav Raj Sigdel <http://www.ncbi.nlm.nih.gov/pubmed/?term=Sigdel KR[auth]>#, Ying Wang <http://www.ncbi.nlm.nih.gov/pubmed/?term=Wang Y[auth]>, Qun Su <http://www.ncbi.nlm.nih.gov/pubmed/?term=Su Q[auth]>, Yan Huang <http://www.ncbi.nlm.nih.gov/pubmed/?term=Huang Y[auth]>, Yan Lin Zhang <http://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang YL[auth]>, Jie Chen <http://www.ncbi.nlm.nih.gov/pubmed/?term=Chen J[auth]>,Lihua Duan <http://www.ncbi.nlm.nih.gov/pubmed/?term=Duan L[auth]>*, Guixiu Shi <http://www.ncbi.nlm.nih.gov/pubmed/?term=Shi G[auth]>*, High Level Serum Procalcitonin Associated Gouty Arthritis Susceptibility: From a Southern Chinese Han Population【查看主页】 , PLoS One【查看主页】 , 2015, 10(7): e0132855
10. Yingying Lin#, Weili Chen, Jiali Li, Guoliang Yan, Chun Li, Ning Jin, Jie Chen, Chang Gao, Pengfei Ma, Shuangyue Xu and Zhongquan Qi*, Overexpression of Jagged-1 combined with blockade of CD40 pathway prolongs allograft survival 【查看主页】, Immunol Cell Biol, 2015, 93(2): 213-217
11. Lihua Duan#, Liying Chen#, Shan Zhong, Ying Wang, Yan Huang, Yan He, Jie Chen, Guixiu Shi*, Treatment of Bullous Systemic Lupus Erythematosus 【查看主页】, J Immunol Res, 2015: 167064
12. Ali Xiong#, Lihua Duan, Jie Chen, Zhigang Fan, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice 【查看主页】, PLoS One, 2012, 7(10): e46230
13. Lihua Duan#, Congyi Wang#, Jie Chen, Quan Gong, Ping Zhu, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response 【查看主页】, Lab Invest, 2011, 91(1): 43-53
14. Ping Zhu#, Lihua Duan, Jie Chen, Ali Xiong, Qin Xu, Hongwei Zhang, Fang Zheng, Zheng Tan, Feili Gong*, Min Fang*, Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice【查看主页】 , Human Gene Therapy, 2011, 22(7): 853-864
15. Guang Yu#, Hong Dai#, Jie Chen, Lihua Duan, Min Gong, Li Liu, Ping Xiong, Congyi Wang, Min Fang*, Feili Gong*, Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses 【查看主页】, J Gene Med, 2008, 10(7): 754-761