厦门大学医学院导师介绍：魏杰

魏杰 

职称：副教授/硕导

学科（方向）：病理生理学/环境表观遗传学
所在系部：基础医学部
办公电话：0592-2880548
邮    箱：jiewei@xmu.edu.cn
研究领域：
环境因素引起机体肥胖、胰岛素抵抗、2型糖尿病等慢性代谢性疾病的表观遗传机制研究。
学习经历：
2000～2005  兰州大学公共卫生学院      医学学士；
2005～2008  兰州大学公共卫生学院      医学硕士；
2008～2011  华中科技大学公共卫生学院  医学博士。
工作经历：
2011.09～2014.03  厦门大学 生命科学学院 博士后；
2014.04～至今厦门大学 医学院 副教授。
代表性成果（* corresponding author; # co-first author）：
Wei J(*), Ding D, Wang T, Liu Q, Lin Y(*). MiR-338 controls BPA-triggered pancreatic islets insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1. FASEB J. 2017, 31(12):5184-5195.

Lin Y(#), Ding D(#), Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J(*), Dong S(*). Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. BBA-Mol Cell Biol L. 2017, 1862(9):869-882.

Wei J(#), Sun X(#), Chen Y, Li Y, Song L, Zhou Z, Xu B, Lin Y(*), Xu S(*). Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. J Endocrinol, 2014, 222(3):313-325.

Wei J(#), Zhang Y(#), Luo Y(*), Song D, Dai Y, Wang T, Yuan L(*), Wen L, Yang JY(*). Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2 and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. Free Radical Bio Med, 2014, 67: 91-102.

Wei J(#), Lin Y(#), Li Y, Ying C, Chen J, Song L, Zhou Z, Lv Z, Xia W, Chen X, Xu S(*). Perinatal exposure to bisphenol A at reference dose, but not at high dose, predispose rat offspring to metabolic syndrome in adulthood. Endocrinology, 2011, 152(8): 3049-3061.

Lin Y(#), Wei J(#), Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S(*). Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol-Endoc M, 2011, 301(3): E527-E538.
主持过的重要课题：
国家自然科学基金青年基金，miR-200a在DEHP暴露致骨骼肌胰岛素抵抗过程中的调控机制研究，2016.01-2018.12.
福建省自然科学基金面上项目，Men1基因调控的表观遗传学修饰在双酚A诱导脂肪细胞分化中的作用研究，2015.04-2018.03.
科研启动经费，DEHP通过miRNA靶向作用胰岛素信号通路致胰岛素抵抗的分子机制探讨，2015.01-2015.12.
中国博士后科学基金，2012M511446、HBx通过抑制AKR7A诱导肝细胞恶性转化的机制研究，2012.05-2013.10.
所有论文列表：
1. Wei J, Ding D, Wang T, Liu Q, Lin Y. MiR-338 controls BPA-triggered pancreatic islet insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1.【查看主页】 FASEB J. 2017 Dec;31(12):5184-5195. doi: 10.1096/fj.201700282R. PMID:28774890
2.  Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong S.Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.【查看主页】Biochim Biophys Acta. 2017, 1862(9):869-882. doi: 10.1016/j.bbalip.2017.05.001. PMID:28483554
3.  Wang T, Hou J, Li Z, Zheng Z, Wei J, Song D, Hu T, Wu Q, Yang JY, Cai JC. miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis.【查看主页】Int J Biol Sci. 2017, 13(1):122-134. doi: 10.7150/ijbs.14770.
4. Jiang C, Chen X, Alattar M,Wei J, Liu H. MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer. 【查看主页】Cancer Gene Ther. 2015 Jun;22(6):291-301. doi: 10.1038/cgt.2015.19. PMID: 25998522
5.  Wei J, Sun X, Chen Y, Li Y, Song L, Zhou Z, Xu B, Lin Y, Xu S. Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet.【查看主页】J Endocrinol. 2014, 222(3):313-25. doi: 10.1530/JOE-14-0356. PMID:25112833
6.  Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH.The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. 【查看主页】J Hepatol. 2014, 61(4):832-9. doi:10.1016/j.jhep. PMID: 24845612
7.  Luo Y, Liu Y, Liu M, Wei J, Zhang Y, Hou J, Huang W, Wang T, Li X, He Y, Ding F, Yuan L, Cai J, Zheng F, Yang JY. Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice.【查看主页】Biochim Biophys Acta. 2014, 1839(2):97-106. doi: 10.1016/j.bbagrm. PMID:24389345
8.  Wei J, Zhang Y, Luo Y, Wang Z, Bi S, Song D, Dai Y, Wang T, Qiu L, Wen L, Yuan L, Yang JY. Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgf?1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. 【查看主页】Free Radic Biol Med. 2014, 67:91-102. doi: 10.1016/j. freeradbiomed. PMID:24161443
9.  Lin Y, Sun X, Qiu L,Wei J, Huang Q, Fang C, Ye T, Kang M, Shen H, Dong S. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells.【查看主页】Cell Death Dis. 2013,17;4:e460. doi: 10.1038/cddis.2012.206.PMID:23328667
10.  Lv Z, Li G, Li Y, Ying C, Chen J, Chen T, Wei J, Lin Y, Jiang Y, Wang Y, Shu B, Xu B, Xu S. Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to perfluorooctane sulfonate.【查看主页】 Environ Toxicol. 2013,28(9):532-42. doi: 10.1002/tox.20747.PMID:23983163
11.  Song L, Xia W, Zhou Z, Li Y, Lin Y, Wei J, Wei Z, Xu B, Shen J, Li W, Xu S. Low-level phenolic estrogen pollutants impair islet morphology and ?-cell function in isolated rat islets. 【查看主页】J Endocrinol. 2012,215(2):303-11. doi: 10.1530/JOE-12-0219. PMID:22946080
12.  Wei Z, Song L, Wei J, Chen T, Chen J, Lin Y, Xia W, Xu B, Li X, Chen X, Li Y, Xu S.Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring.【查看主页】 Toxicol Lett. 2012,212(2):212-21. doi: 10.1016/j.toxlet.2012.05.023.PMID:22677342
13.  Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S.Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat.【查看主页】 Am J Physiol Endocrinol Metab. 2011, 301(3):E527-38. doi: 10.1152/ajpendo.00233.2011. PMID: 21673306
14.  Wei J, Lin Y, Li Y, Ying C, Chen J, Song L, Zhou Z, Lv Z, Xia W, Chen X, Xu S.Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet. 【查看主页】Endocrinology. 2011, 152(8):3049-61. doi: 10.1210/en.2011-0045. Epub 2011 May 17. PMID: 21586551
15.  Zeng HC, Zhang L, Li YY, Wang YJ, Xia W, Lin Y, Wei J, Xu SQ. Inflammation-like glial response in rat brain induced by prenatal PFOS exposure. 【查看主页】Neurotoxicology. 2011, 32(1):130-9. doi: 10.1016/j.neuro.2010.10.001. PMID: 20937303
16. Zhang L, Li YY, Zeng HC, Wei J, Wan YJ, Chen J, Xu SQ. MicroRNA expression changes during zebrafish development induced by perfluorooctane sulfonate. 【查看主页】J Appl Toxicol. 2011,31(3):210-22. doi: 10.1002/jat.1583. PMID:20878907
17.  Zeng HC, Li YY, Zhang L, Wang YJ, Chen J, Xia W, Lin Y, Wei J, Lv ZQ, Li M, Xu SQ.Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin.【查看主页】 Synapse. 2011, 65(3):225-33. doi: 10.1002/syn.20840. PMID:20687110
18.  Wan YJ, Li YY, Xia W, Chen J, Lv ZQ, Zeng HC, Zhang L, Yang WJ, Chen T, Lin Y, Wei J, Xu SQ. Alterations in tumor biomarker GSTP gene methylation patterns induced by prenatal exposure to PFOS.【查看主页】 Toxicology. 2010, 274(1-3):57-64. doi: 10.1016/j.tox.2010.05.006.PMID: 20621739
19.  Xia W, Li Y, Wan Y, Chen T, Wei J, Lin Y, Xu S. Electrochemical biosensor for estrogenic substance using lipid bilayers modified by Au nanoparticles. 【查看主页】Biosens Bioelectron. 2010, 15;25(10):2253-8. doi: 10.1016/j.bios.2010.03.004. PMID: 20353888