厦门大学医学院导师介绍：张云武

主要学术成果：

论文：

1

Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW* (2016) The neuron-specific protein TMEM59L mediates oxidative stress-induced cell death. Mol Neurobiol, June 21. [Epub ahead of print].

2

Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW* (2016) Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. J Cell Sci 129: 994-1002

3

Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW* (2015) SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation.Mol Neurobiol，[Epub ahead of print]

4

Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y, Cohen SN, Li L,Zhang YW*, Luo H*, Tu S*, Xu H* (2016) RPS23RG1 reduces Ab oligomer-induced synaptic and cognitive deficits. Sci Rep 6:18668. (*: co-corresponding authors)

5

Hu J, Lin T, Xu J, Ding R, Wang G, Shen R, Zhang YW*, Chen H* (2016) Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway. Bioorganic & Medicinal Chemistry Letters 26: 505-511. (*: co-corresponding authors)

6

Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Bu G, Xu H, Xing H, Zhang YW*, Zheng W* (2016) miR-219 protects against seizure in the kainic acid model of epilepsy. Mol Neurobiol, 53: 1-7. (*: co-corresponding authors)

7

Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW* (2015)The role of copper and the copper-related protein CUTA in mediating APP processing and Ab generation. Neurobiol Aging36: 1310-1315

8

Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW* (2015) The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation. Plos ONE 10: e0115973.

9

Zheng KM, Zhang J, Zhang CL, Zhang YW*, Chen XC* (2015) Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells. Acta Pharmacol Sin 36(5):544-552. (*: co-corresponding authors)

10

Zhang X, Li Y, Xu H, Zhang YW* (2014) The g-secretase complex: from structure to function. Front Cell Neurosci 8:427.

11

Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW* (2014) Trafficking regulation of proteins in Alzheimer’s disease. Mol Neurodegener 9:6.

12

Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW* (2014) M1 muscarinic acetylcholine receptor in Alzheimer’s disease. Neurosci Bull 30: 295-307.

13

Zhang YW*, Chen Y, Liu Y, Zhao Y, Liao FF, Xu H* (2013) APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival. Plos ONE 8(11): e80571. doi:10.1371/journal.pone.0080571. (*: co-corresponding authors)

14

Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW* (2013) Ferritin light chain interacts with PEN-2 and affectsγ-secretase activity. Neurosci Lett 548: 90-94.

15

Zhang H#, Zhang YW#, Chen Y#, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JDJ, Bu G, Reed JC, Liao FF, Chen YG, Xu H (2012) Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration. J Neurosci 32: 15565-15576. (#:co-first authors)

16

Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang YW* (2012) Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Mol Neurodegener 7:30.

17

Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW* (2012) CutA divalent cation tolerance homolog (E. Coli) (CUTA) regulates β-cleavage of β-amyloid precursor proteins (APP) through interacting with β-site APP cleaving protein 1 (BACE1).J Biol Chem 287: 11141-11150.

18

Huang X, Chen Y, Li W-B, Cohen SN, Liao F-F, Li L, Xu H, Zhang YW* (2010) The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer’s b-amyloid level and tau phosphorylation. Hum Mol Genet 19: 3835-3843.

19

Jiang S, Wang Y, Ma Q, Zhou A, Zhang X, Zhang YW* (2012) M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation. Neurosci Lett 515: 125-130

20

Zhang YW, Xu H (2010) Substrate check of g-secretase. Nat Struct Mol Biol17: 140-141.

21

Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H. (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s b-amyloid levels and tau phosphorylation. Neuron 64：328-340.

22

Zhang YW*, Wang R, Liu Q, Zhang H, Liao FF, Xu H* (2007) Presenilin/ g-secretase-dependent processing of APP regulates EGFR expression. Proc Natl Acad Sci USA 104: 10613-10618. (*: co-corresponding authors)

主持课题：

1

国家自然科学基金重大研究计划培育项目“RPS23RG家族在海马神经环路功能和学习记忆中的作用研究”（2014.01-2016.12），70万元

2

国家杰出青年科学基金“老年痴呆症的细胞与分子机制”（2013.01-2016.12），280万元

3

国家自然科学基金中加（NSFC-CIHR）老年痴呆症及相关病症合作研究项目“一个新的与APP相互作用的促凋亡蛋白在老年痴呆症中的功能机制”（2012.01-2015.12），300万元

4

美国Alzheimer’s Association项目“The Involvement of CutA in Alzheimer’s Disease”（2010.09-2012.08），8万美元

5

科技部973前期专项“在老年性痴呆症中起重要作用的新基因的鉴定及功能研究”（2010.04-2012.08），62万元

获奖：

1

2008年教育部新世纪优秀人才支持计划

2

2009年福建省“杰出青年基金”

3

2012年福建省“高校领军人才”

4

2012年“国家杰出青年科学基金”

5

2014年福建省“科技创新领军人才”