厦门大学材料学院导师介绍：侯振清

  姓名：侯振清
  职称：教授
  电话：0592-2189650（实验室）
  传真：0592-2183937
  邮箱：houzhenqing@xmu.eud.cn
  个人简历
  研究工作经历:
  1985/08-1990/10，山东新泰市人民医院，制剂室，药师；
  1994/08-1996/07，山东鲁抗制药股份有限公司，研发部，工程师；
  1996/08-1999/08，济宁市第一医院，制剂中心主任，主管药师；
  1999/08-2000/08，西安交通大学，生物医学工程研究所，访问学者；
  2005/04-至今，厦门大学材料学院生物材料系、厦门大学生物仿生与软物质研究院，教授（2005.4-2010.8讲师，2010.9-2014.8副教授，2014.8-至今 教授）。
  教育经历:
  1981/09-1985/07，山东大学，药学系药学专业，学士；
  1991/09-1994/07，中国药科大学，生物技术学院生化制药专业，硕士；
  2000/09-2004/06，西安交通大学，生物医学工程研究所，生物医学工程专业，博士。
  研究领域
  主要从事药物控缓释制剂及生物材料方面的研究工作，近年来重点研究方向为抗肿瘤药物控缓释和骨折材料的研究。
  主要科研成果
  主持和参与了国家973项目1项，国家支撑计划项目1项，多项国家自然科学基金，多项厦门市科技计划项目；另外，与企业和医院横向合作项目4项。研究成果先后在Journal of Controlled Release，Chemical Science, Mol. Pharmoceutics等杂志上发表论文40多篇。
  主要代表学术论著与论文
  [1] Jia Mengmeng, Li Yang, Yang Xiangrui, Huang Yuancan, Wu Hongjie, Huang Yu, Lin Jinyan, Li Yanxiu, Hou Zhenqing, Zhang Qiqing. Development of Both Methotrexate and Mitomycin C Loaded PEGylated Chitosan Nanoparticles for Targeted Drug Codelivery and Synergistic Anticancer Effect[J]. ACS Appl. Mater. Interfaces, 2014, 6: 11413-11423.
  [2] Li Yang, Lin Jinyan, Huang Yu, Li Yanxiu, Yang Xiangrui, Wu Hongjie, Wu Shichao, Xie Liya, Dai Lizong, Hou Zhenqing. Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells[J]. ACS Appl. Mater. Interfaces, 2015, 7: 25553-25559.
  [3] Li Yang, Lin Jinyan, Yang Xiangrui, Li Yanxiu, Wu Shichao, Huang Yu, Ye Shefang, Xie Liya, Dai Lizong, Hou Zhenqing. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release[J]. ACS Appl. Mater. Interfaces, 2015, 7: 17573-17581.
  [4] Lin Jinyan, Li Yang, Li Yanxiu, Wu Hongjie, Yu Fei, Zhou Shuifan, Xie Liya, Luo Fanghong, Lin Changjian, Hou Zhenqing. Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging[J]. ACS Appl. Mater. Interfaces, 2015, 7: 11908-11920.
  [5] Li Yang, Lin Jinyan, Wu Hongjie, Jia Mengmeng, Yuan Conghui, Chang Ying, Hou Zhenqing, Dai Lizong. Novel Methotrexate Prodrug-Targeted Drug Delivery System Based on PEG-Lipid-PLA Hybrid Nanoparticles for Enhanced Anticancer Efficacy and Reduced Toxicity of Mitomycin C[J]. J. Mater. Chem. B, 2014, 2: 6534-6548.
  [6] Lin Jinyan, Li Yanxiu, Li Yang, Cui Fei, Yu Fei, Wu Hongjie, Xie Liya, Luo Fanghong, Hou Zhenqing, Lin Changjian. Self-Targeted, Bacillus-Shaped, and Controlled-Release Methotrexate Prodrug Polymeric Nanoparticles for Intratumoral Administration with Improved Therapeutic Efficacy in Tumor-Bearing Mice[J]. J. Mater. Chem. B, 2015, 3: 7707-7717.
  [7] Cui Fei, Lin Jinyan, Li Yang, Li Yanxiu, Wu Hongjie, Yu Fei, Jia Mengmeng, Yang Xiangrui, Wu Shichao, Xie Liya, Ye Shefang, Luo Fanghong, Hou Zhenqing. Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy[J]. Mol. Pharmaceutics, 2015, 12: 1318-1327.
  [8] Hou Zhenqing, Li Yang, Huang Yuancan, Zhou Chunxiao, Lin Jinyan, Wang Yixiao, Cui Fei, Zhou Shuifan, Jia Mengmeng, Ye Shefang, Zhang Qiqing. Phytosomes Loaded with Mitomycin C-Soybean Phosphatidylcholine Complex Developed for Drug Delivery[J]. Mol. Pharmaceutics, 2013, 10: 90-101.
  [9] Li Yang, Lin Jinyan, Wu Hongjie, Chang Ying, Yuan Conghui, Liu Cheng, Wang Shuang, Hou Zhenqing, Dai Lizong. Orthogonally Functionalized Nanoscale Micelles for Active Targeted Codelivery of Methotrexate and Mitomycin C with Synergistic Anticancer Effect[J]. Mol. Pharmaceutics, 2015, 12: 769-782.
  [10] Li Yang, Wu Hongjie, Jia Mengmeng, Cui Fei, Lin Jinyan, Yang Xiangrui, Wang Yange, Dai Lingfeng, Hou Zhenqing. Therapeutic Effect of Folate-Targeted and PEGylated Phytosomes Loaded with a Mitomycin C-Soybean Phosphatidyhlcholine Complex[J]. Mol. Pharmaceutics, 2014, 11: 3017-3026.
  [11] Li Yang, Wu Hongjie, Yang Xiangrui, Jia Mengmeng, Li Yanxiu, Huang Yu, Lin Jinyan, Wu Shichao, Hou Zhenqing. Mitomycin C-Soybean Phosphatidylcholine Complex-Loaded Self-Assembled PEG-Lipid-PLA Hybrid Nanoparticles for Targeted Drug Delivery and Dual-Controlled Drug Release[J]. Mol. Pharmaceutics, 2014, 11: 2915-2927.
  [12] Zhou Shuifan, Li Yang, Cui Fei, Jia Mengmeng, Yang Xiangrui, Wang Yange, Xie Liya, Zhang Qiqing, Hou Zhenqing. Development of Multifunctional Folate-Poly(Ethylene Glycol)-Chitosan-Coated Fe3O4 Nanoparticles for Biomedical Applications[J]. Macromol. Res., 2014, 22: 58-66.
  [13] Cui Fei, Li Yang, Zhou Shuifan, Jia Mengmeng, Yang Xiangrui, Yu Fei, Ye Shefang, Hou Zhenqing, Xie Liya. A Comparative in Vitro Evaluation of Self-Assembled PTX-PLA and PTX-MPEG-PLA Nanoparticles[J]. Nanoscale Res. Lett., 2013, 8: 301.
  [14] Hou Zhenqing, Wang Yixiao, Shen Lihua, Guo Hao, Wang Gongxin, Li Yang, Zhou Shuifan, Zhang Qiqing, Jiang Qian. Synthesis of Dumbbell-Like ZnO Microcrystals Via a Simple Solution Route[J]. Nanoscale Res. Lett., 2012, 7: 507.
  [15] Hou Zhenqing, Zhan Chuanming, Jiang Qiwei, Hu Quan, Li Le, Chang Di, Yang Xiangrui, Wang Yixiao, Li Yang, Ye Shefang, Xie Liya, Yi Yunfeng, Zhang Qiqing. Both FA- and mPEG-Conjugated Chitosan Nanoparticles for Targeted Cellular Uptake and Enhanced Tumor Tissue Distribution[J]. Nanoscale Res. Lett., 2011, 6: 563.
  [16] Luo Fanghong, Li Yang, Jia Mengmeng, Cui Fei, Wu Hongjie, Yu Fei, Lin Jinyan, Yang Xiangrui, Hou Zhenqing, Zhang Qiqing. Validation of a Janus Role of Methotrexate-Based PEGylated Chitosan Nanoparticles in Vitro[J]. Nanoscale Res. Lett., 2014, 9: 363.
  [17] Yang Xiangrui, Wu Shichao, Wang Yange, Li Yang, Chang Di, Luo Ying, Ye Shefang, Hou Zhenqing. Evaluation of Self-Assembled HCPT-Loaded PEG-B-PLA Nanoparticles by Comparing with HCPT-Loaded PLA Nanoparticles[J]. Nanoscale Res. Lett., 2014, 9: 2408.
  [18] Yi Yunfeng, Li Yang, Wu Hongjie, Jia Mengmeng, Yang Xiangrui, Wei Heng, Lin Jinyan, Wu Shichao, Huang Yu, Hou Zhenqing, Xie Liya. Single-Step Assembly of Polymer-Lipid Hybrid Nanoparticles for Mitomycin C Delivery[J]. Nanoscale Res. Lett., 2014, 9: 560.
  [19] Yi Yunfeng, Zhang Ying, Wang Yixiao, Shen Lihua, Jia Mengmeng, Huang Yu, Hou Zhenqing, Zhuang Guohong. Ethylenediaminetetraacetic Acid as Capping Ligands for Highly Water-Dispersible Iron Oxide Particles[J]. Nanoscale Res. Lett., 2014, 9: 1-7.
  [20] Hou Zhenqing, Lin Jinyan, Li Yanxiu, Guo Fuqiang, Yu Fei, Wu Hongjie, Fan Zhongxiong, Zhi Lili, Luo Fanghong. Validation of a Dual Role of Methotrexate-Based Chitosan Nanoparticles in Vivo[J]. RSC Adv., 2015, 5: 41393-41400.
  [21] Lin Jinyan, Li Yang, Wu Hongjie, Yang Xiangrui, Li Yanxiu, Ye Shefang, Hou Zhenqing, Lin Changjian. Tumor-Targeted Co-Delivery of Mitomycin C and 10-Hydroxycamptothecin Via Micellar Nanocarriers for Enhanced Anticancer Efficacy[J]. RSC Adv., 2015, 5: 23022-23033.
  [22] Hou Zhenqing, Zhou Chunxiao, Luo Ying, Zhan Chuanming, Wang Yixiao, Xie Liya, Zhang Qiqing. PLA Nanoparticles Loaded with an Active Lactone Form of Hydroxycamptothecin: Development, Optimization, and in Vitro–in Vivo Evaluation in Mice Bearing H22 Solid Tumor[J]. Drug Develop. Res., 2011, 72: 337-345.
  [23] Hou Zhenqing, Li Le, Zhan Chuanming, Zhu Peijuan, Chang Di, Jiang Qiwei, Ye Shefang, Yang Xiangrui, Li Yang, Xie Liya, Zhang Qiqing. Preparation and in Vitro Evaluation of an Ultrasound-Triggered Drug Delivery System: 10-Hydroxycamptothecin Loaded PLA Microbubbles[J]. Ultrasonics, 2012, 52: 836-841.
  [24] Yang Xiangrui, Wu Shichao, Li Yang, Huang Yu, Lin Jinyan, Chang Di, Ye Shefang, Xie Liya, Jiang Yuan, Hou Zhenqing. Integration of an Anti-Tumor Drug into Nanocrystalline Assemblies for Sustained Drug Release[J]. Chem. Sci., 2015, 6: 1650-1654.
  [25] Wang Yixiao, Hou Zhenqing, Guo Hao, Shen Lihua, Wang Gongxin, Cui Fei, Zhang Qiqing. Preparation of ZnO Nanorods Via Aqueous Solution Process and Their Pl Properties[J]. Mater. Lett., 2013, 91: 107-110.