厦门大学化学化工学院化学生物学系导师介绍：朱志

  朱志
  通讯地址：厦门大学化学化学化工学院，邮编361005
  电子邮件: zhuzhi@xmu.edu.cn
  课题组网页：http://www.yang-lab.com/
  更新个人信息
  个人简历：
  2002.09-2006.07 北京大学化学与分子工程学院，学士
  2006.08-2011.05 佛罗里达大学化学系，博士
  2011.08-2012.01 厦门大学化学化工学院，助理教授
  2012.01-2015.08 厦门大学化学化工学院，副教授
  2015.08-至今       厦门大学化学化工学院，教授
  2016.11-至今       厦门大学化学化工学院，特聘教授
  先后获得美国化学会分析化学研究生奖、中国政府优秀自费留学生奖、国家优秀青年基金、中国化学会青年化学奖等奖项。
  担任Nature子刊Scientific Reports编委，《中国化学快报》、《分析测试学报》青年编委。
  研究兴趣：
  生物化学及生物分析方向，包括： 1．分子识别与传感 2．信号放大方法 3．微流控生物分析
  近期主要代表论著：
  Liu, D; Jia, S; Zhang, H; Ma, Y; Guan, Z; Li, J; Zhu, Z*; Ji, T; Yang, C*. Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-friendly, Quantitative Point-of-Care Testing, ACS Appl. Mater. Interfaces, 2017, 9, 22252-22258.
  Zhu, Z; Yang, C. “Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis.” Acc. Chem. Res. 2017, 50, 22–31.
  Xie, Y; Wei, X; Yang, Q; Guan, Z; Liu, D; Liu, X; Zhou, L; Zhu, Z*; Lin, Z*; Yang, C*. “Shake&Read Distance-based Microfluidic Chip as a Portable Quantitative Readout Device for Highly Sensitive Point-of-Care Testing.” Chem. Commun., 2016, 52, 13377-13380.
  Ma, Y; Mao, Y; Huang, D; He, Z; Yan, J; Tian, T; Shi, Y; Song, Y; Li, X; Zhu, Z*; Zhou, L; Yang, C. “Portable Visual Quantitative Detection of Aflatoxin B1 Using a Target-Responsive Hydrogel and Distance-Readout Microfluidic Chip.” Lab Chip, 2016, 16, 3097-3104.
  Huang, Y; Fang, L; Zhu, Z*; Ma, Y; Zhou, L; Chen, X; Xu, D; Yang, C*. “Design and synthesis of target-responsive hydrogel for portable visual quantitative detection of uranium with a microfluidic distance-based readout device.” Biosensors Bioelectronics, 2016, 85, 496-502.
  Tan, Y; Tian, T; Liu, W; Zhu, Z*; Yang, C. “Advance in phage display technology for bioanalysis.” Biotechnol J, 2016, 11, 732-745.
  Tian, T; Li, J; Song,Y; Zhou, L; Zhu, Z*; Yang, C*. “Distance-based Microfluidic Quantitative Detection Methods for Point-of-Care Testing.” Lab Chip, 2016, 16, 1139-1151.
  Zhang, W; Zu, X; Song, Y; Zhu, Z*; Yang, C*. “Detection of DNA Methyltransferase Activity using Allosteric Molecular Beacons.” Analyst, 2016, 141, 579-584.
  Tian, T; Wei, X; Jia, S; Zhang, R; Li, J; Zhu, Z*; Zhang, H; Ma, Y; Lin, Z; Yang, C.* “Integration of target responsive Hydrogel with cascaded enzymatic Reactions and microfluidic paper-based analytic Devices (?PADs) for point-of-care testing (POCT).” Biosensors Bioelectronics, 2015, 77, 537-542.
  Zhu, Z; Guan, Z; Liu, D; Jia, S; Li, J; Lei, Z; Lin, S; Ji, T; Tian, Z; Yang, C. “Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis.” Angew. Chem. Int. Ed., 2015, 54, 10448-10453. (共同一作) (Frontipiece Paper)
  Liu, R; Huang, Y; Ma, Y; Jia, S; Gao, M; Li, J; Zhang, H; Xu, D; Wu, M; Chen, Y; Zhu, Z*; Yang C*. “Design and Synthesis of Target-Responsive Aptamer-Crosslinked Hydrogel for Visual Quantitative Detection of Ochratoxin A.” ACS Appl. Mater. Interfaces, 2015, 7, 6982-6990.
  Huang, Y; Ma, Y; Chen, Y; Wu, X; Fang, L; Zhu, Z*; Yang, C*. “Target-Responsive DNAzyme Crosslinked Hydrogel for Visual Quantitative Detection of Lead.” Anal. Chem., 2014, 86, 11434–11439.
  Ke, G; Zhu, Z*; Wang, W; Zou, Y; Guan, Z; Jia S; Zhang, H; Wu, X; Yang, C*. “A Cell Surface-Anchored Ratiometric Fluorescent Probe for Extracellular pH Sensing”, ACS Applied Materials & Interfaces, 2014, 6, 15329–15334.
  Zhu, Z; Guan, Z; Jia, S; Lei, Z; Lin, S; Zhang, H; Ma, Y; Tian, Z-Q; Yang, C. “Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing.” Angew. Chem. Int. Ed., 2014,  53, 12503–12507. (共同一作)
  Lin, H; Zhang, W; Jia, S; Guan, Z; Yang, C; Zhu, Z*. “Microfluidic Approaches to Rapid and Efficient Aptamer Selection.” Biomicrofluidics, 2014, 8, 041501.
  Zhu, Z; Song Y; Li, C; Zou, Y; Zhu, L; An, Y; Yang, C. “Monoclonal Surface Display SELEX for Simple, Rapid, Efficient and Cost-Effective Aptamer Enrichment and Identification.” Anal. Chem., 2014, 86, 5881-5888. (共同一作)
  Lin, X; Cui, L; Huang, Y; Lin, Y; Xie, Y; Zhu, Z*; Yin, B; Chen, X; Yang, C*. “Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules Based on Nuclease-Assisted Target Recycling Signal Amplification.” Chem. Commun., 2014, 50, 7646-7648.
  Zhang, H; Song, Y; Zou, Y; Ge, Y; An, Y; Ma, Y; Zhu, Z*; Yang, C*. “A Diazirine-Based Photoaffinity Probe for Facile and Efficient Aptamer-Protein Covalent Conjugation.” Chem. Commun., 2014, 50, 4891-4894.
  Guan, Z; Jia S; Zhu, Z; Zhang, M; Yang, C. “Facile and Rapid Generation of Large-scale Micro-collagen-gel Array for Long-term Single Cell 3D Culture and Cell Proliferation Heterogeneity Analysis.” Anal. Chem., 2014, 86, 2789-2797. (共同一作)
  Cui, L; Zhu, Z*; Lin, L; Zhang, H; Guan, Z; Yang, C*. “Exonuclease-Assisted Cyclic Enzymatic Amplification Method Coupled with Rolling Circle Amplification: A Dual-amplification Strategy for Sensitive and Selective MicroRNA Detection.” Chem. Commun., 2014, 50, 1576-1578.
  Cui, L; Ke, G; Lin, X; Song, Y; Zhang, H; Guan, Z; Zhu, Z*; Yang, C. “Cyclic Enzymatic Amplification Method (CEAM) Based on Exonuclease III for Highly Sensitive Bioanalysis.” Methods, 2013, 63, 202-211.
  Cui, L; Song, Y; Ke, G; Guan, Z; Zhang, H; Lin, Y; Huang, Y; Zhu, Z*; Yang, C*. “Graphene Oxide Protected Nucleic Acid Probes for Bioanalysis and Biomedicine.” Chem. Eur. J., 2013, 19, 10442-10451.
  Lin, X; Zhang, C; Huang, Y; Zhu, Z*; Chen, X; Yang, C*. “Backbone-modified Molecular Beacons for highly Sensitive and Selective Detection of microRNAs Based on Duplex Specific Nuclease Signal Amplification.” Chem. Commun., 2013, 49, 7243-7245.
  Song, Y; Zhu, Z*; An, Y; Zhang, W; Zhang, H; Liu, D; Yu, C; Duan, W*; Yang, C*. “Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Imaging and Circulating Tumor Cell Capturing.” Anal. Chem., 2013, 85, 4141-4149.
  Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” J. Am. Chem. Soc., 2013, 135, 3748-3751. (共同一作) (Cover paper & JACS Spotlights)
  Han, D; Zhu, Z; Wu, C; Peng, L; Zhou, L; Gulbakan, B; Zhu, G; Williams, K R; Tan, W. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.” J. Am. Chem. Soc, 2012, 134, 20797-20804. (共同一作) (ACS C&EN News)
  Zhu, L; Li, C; Zhu, Z; Liu, D; Zou, Y; Wang, C; Fu, H; Yang, C. “In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes.” Anal. Chem., 2012, 84, 8383-8390. (共同一作)
  Wu, J; Wang, C; Li, X; Song, Y; Wang, W; Li, C; Hu, J; Zhu, Z*; Li, J; Zhang, W; Lu, Z*; Yang, C*. “Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2.” Plos One, 2012, 7, e46393.
  Li, C; Zhu, L; Zhu, Z; Fu, H; Jenkins, G; Wang, C; Zou, Y; Lu, X; Yang, C. “Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme.” Chem. Commun., 2012, 48, 8347-8349. (共同一作)
  Zhu, Z; Zhang, W; Leng, X; Zhang, M; Guan, Z; Yang, C. “Highly Sensitive and Quantitative Detection of Rare Pathogens through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level.” Lab Chip, 2012, 12, 3907-3913. (共同一作)
  Zhu, Z; Jenkins, G; Zhang, W; Zhang, M; Guan, Z; Yang, C. “Single-Molecule Emulsion PCR in Microfluidic Droplet.” Anal. Bioanal. Chem., 2012, 403, 2127-2143.
  Song, Y; Zhang, W; An, Y; Cui, L; Yu, C; Zhu, Z*; Yang, C*. “Label-free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability.” Chem. Commun., 2012, 48, 576–578.
  Pu, Y; Zhu, Z; Han, D; Liu, H; Liu, J; Liao, J; Zhang, K; Tan, W. “Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection.” Analyst, 2011, 47, 4138-4140. (共同一作)
  Wang, C; Zhu, Z; Song, Y; Lin, H; Yang, C; Tan, W. “Caged Molecular Beacons: Controlling Nucleic Acid Hybridization with Light.” Chem. Commun., 2011, 47, 5708-5710. (共同一作)
  Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C; Tan, W. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056. (Frontipiece Paper)